EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report

Autoimmune encephalitis (AE) is a group of inflammatory brain diseases that are characterized by prominent neuropsychiatric symptoms. Early therapeutic intervention is important for AE. Therefore, without waiting for autoantibody test results, clinicians must consider the possibility of AE based sol...

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Autores principales:	Mayusa Mito, Kotaro Sakurai, Yuichi Nakamura, Azusa Nagai, Sho Seo, Keiko Tanaka, Ichiro Yabe, Ichiro Kusumi
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	autoimmune diseases diagnosis electroencephalography encephalitis seizures Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bf7d89eb1586448ba5e4fda6af6f7783
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spelling	oai:doaj.org-article:bf7d89eb1586448ba5e4fda6af6f77832021-12-02T12:40:22ZEEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report1662-680X10.1159/000519991https://doaj.org/article/bf7d89eb1586448ba5e4fda6af6f77832021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/519991https://doaj.org/toc/1662-680XAutoimmune encephalitis (AE) is a group of inflammatory brain diseases that are characterized by prominent neuropsychiatric symptoms. Early therapeutic intervention is important for AE. Therefore, without waiting for autoantibody test results, clinicians must consider the possibility of AE based solely on clinical symptoms and conventional test results. The case described herein is of antibody-negative encephalitis with abnormalities shown only by EEG, which contributed to the diagnosis and treatment. The patient, a 20-year-old woman, showed autonomic seizures in addition to movement disorders, psychiatric symptoms, and cognitive dysfunction, which worsened subacutely. Her seizures and movement disorders were not responsive to antiepileptic medications. Results obtained from MRI and cerebrospinal fluid (CSF) were normal; EEG findings showed repeated spikes in the right temporal area, with changes over time. Based on the clinical course and EEG, along with administered immunotherapy, which resolved seizures, movement disorders, and psychiatric symptoms, we suspected AE. For diagnosis of AE and for evaluating treatment responsiveness, EEG was useful. Results indicate that EEG can assist clinicians even with AE cases for which MRI and CSF findings are normal.Mayusa MitoKotaro SakuraiYuichi NakamuraAzusa NagaiSho SeoKeiko TanakaIchiro YabeIchiro KusumiKarger Publishersarticleautoimmune diseasesdiagnosiselectroencephalographyencephalitisseizuresNeurology. Diseases of the nervous systemRC346-429ENCase Reports in Neurology, Vol 13, Iss 3, Pp 739-743 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoimmune diseases diagnosis electroencephalography encephalitis seizures Neurology. Diseases of the nervous system RC346-429
spellingShingle	autoimmune diseases diagnosis electroencephalography encephalitis seizures Neurology. Diseases of the nervous system RC346-429 Mayusa Mito Kotaro Sakurai Yuichi Nakamura Azusa Nagai Sho Seo Keiko Tanaka Ichiro Yabe Ichiro Kusumi EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report
description	Autoimmune encephalitis (AE) is a group of inflammatory brain diseases that are characterized by prominent neuropsychiatric symptoms. Early therapeutic intervention is important for AE. Therefore, without waiting for autoantibody test results, clinicians must consider the possibility of AE based solely on clinical symptoms and conventional test results. The case described herein is of antibody-negative encephalitis with abnormalities shown only by EEG, which contributed to the diagnosis and treatment. The patient, a 20-year-old woman, showed autonomic seizures in addition to movement disorders, psychiatric symptoms, and cognitive dysfunction, which worsened subacutely. Her seizures and movement disorders were not responsive to antiepileptic medications. Results obtained from MRI and cerebrospinal fluid (CSF) were normal; EEG findings showed repeated spikes in the right temporal area, with changes over time. Based on the clinical course and EEG, along with administered immunotherapy, which resolved seizures, movement disorders, and psychiatric symptoms, we suspected AE. For diagnosis of AE and for evaluating treatment responsiveness, EEG was useful. Results indicate that EEG can assist clinicians even with AE cases for which MRI and CSF findings are normal.
format	article
author	Mayusa Mito Kotaro Sakurai Yuichi Nakamura Azusa Nagai Sho Seo Keiko Tanaka Ichiro Yabe Ichiro Kusumi
author_facet	Mayusa Mito Kotaro Sakurai Yuichi Nakamura Azusa Nagai Sho Seo Keiko Tanaka Ichiro Yabe Ichiro Kusumi
author_sort	Mayusa Mito
title	EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report
title_short	EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report
title_full	EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report
title_fullStr	EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report
title_full_unstemmed	EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report
title_sort	eeg contribution to the diagnosis of antibody-negative autoimmune encephalitis: a case report
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/bf7d89eb1586448ba5e4fda6af6f7783
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EEG Contribution to the Diagnosis of Antibody-Negative Autoimmune Encephalitis: A Case Report

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