Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy
Abstract Gastrointestinal mucositis is a complication of anticancer treatment, with few validated in vitro systems suitable to study the complex mechanisms of mucosal injury. Therefore, we aimed to develop and characterize a chemotherapeutic-induced model of mucositis using 3D intestinal organoids....
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Main Authors: | A. R. da Silva Ferreira, S. A. J. van der Aa, T. Wehkamp, H. R. Wardill, J. P. ten Klooster, J. Garssen, L. F. Harthoorn, A. Hartog, H. J. M. Harmsen, W. J. E. Tissing, J. van Bergenhenegouwen |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Online Access: | https://doaj.org/article/bf7e652cdc60485a8c52e953e31c3dd1 |
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