Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy

Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy

Abstract Gastrointestinal mucositis is a complication of anticancer treatment, with few validated in vitro systems suitable to study the complex mechanisms of mucosal injury. Therefore, we aimed to develop and characterize a chemotherapeutic-induced model of mucositis using 3D intestinal organoids....

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Main Authors: A. R. da Silva Ferreira, S. A. J. van der Aa, T. Wehkamp, H. R. Wardill, J. P. ten Klooster, J. Garssen, L. F. Harthoorn, A. Hartog, H. J. M. Harmsen, W. J. E. Tissing, J. van Bergenhenegouwen
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/bf7e652cdc60485a8c52e953e31c3dd1
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https://doaj.org/article/bf7e652cdc60485a8c52e953e31c3dd1

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