Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy

Abstract The aim of the present work is to describe the differences in rs-fMRI measures (Amplitude of low frequency fluctuations [ALFF], Regional Homogeneity [ReHo] and Functional Connectivity [FC]) between patients exposed to Androgen deprivation therapy (ADT) and a control group. Forty-nine ADT pa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julio Plata-Bello, Ana Plata-Bello, Yaiza Pérez-Martín, David López-Curtis, Silvia Acosta-López, Cristián Modroño, Tomás Concepción-Massip
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf7f30e55aec49faa3b86f690b922ff0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf7f30e55aec49faa3b86f690b922ff0
record_format	dspace
spelling	oai:doaj.org-article:bf7f30e55aec49faa3b86f690b922ff02021-12-05T12:11:57ZChanges in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy10.1038/s41598-021-02611-62045-2322https://doaj.org/article/bf7f30e55aec49faa3b86f690b922ff02021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02611-6https://doaj.org/toc/2045-2322Abstract The aim of the present work is to describe the differences in rs-fMRI measures (Amplitude of low frequency fluctuations [ALFF], Regional Homogeneity [ReHo] and Functional Connectivity [FC]) between patients exposed to Androgen deprivation therapy (ADT) and a control group. Forty-nine ADT patients and fifteen PC-non-ADT patients (Controls) were included in the study. A neuropsychological evaluation and a resting-state fMRI was performed to evaluate differences in ALFF and ReHo. Region of interest (ROI) analysis was also performed. ROIs were selected among those whose androgen receptor expression (at RNA-level) was the highest. FC analysis was performed using the same ROIs. Higher ALFF in frontal regions and temporal regions was identified in Controls than in ADT patients. In the ROI analysis, higher activity for Controls than ADT patients was shown in the left inferior frontal gyrus and in the left precentral gyrus. Lower ALFF in the right hippocampus and the lateral geniculate nucleus of the right thalamus was identified for Controls than ADT patients. Higher ReHo was observed in Controls in the left parietal-occipital area. Finally, ADT patients presented an increase of FC in more regions than Controls. These differences may reflect an impairment in brain functioning in ADT users.Julio Plata-BelloAna Plata-BelloYaiza Pérez-MartínDavid López-CurtisSilvia Acosta-LópezCristián ModroñoTomás Concepción-MassipNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julio Plata-Bello Ana Plata-Bello Yaiza Pérez-Martín David López-Curtis Silvia Acosta-López Cristián Modroño Tomás Concepción-Massip Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy
description	Abstract The aim of the present work is to describe the differences in rs-fMRI measures (Amplitude of low frequency fluctuations [ALFF], Regional Homogeneity [ReHo] and Functional Connectivity [FC]) between patients exposed to Androgen deprivation therapy (ADT) and a control group. Forty-nine ADT patients and fifteen PC-non-ADT patients (Controls) were included in the study. A neuropsychological evaluation and a resting-state fMRI was performed to evaluate differences in ALFF and ReHo. Region of interest (ROI) analysis was also performed. ROIs were selected among those whose androgen receptor expression (at RNA-level) was the highest. FC analysis was performed using the same ROIs. Higher ALFF in frontal regions and temporal regions was identified in Controls than in ADT patients. In the ROI analysis, higher activity for Controls than ADT patients was shown in the left inferior frontal gyrus and in the left precentral gyrus. Lower ALFF in the right hippocampus and the lateral geniculate nucleus of the right thalamus was identified for Controls than ADT patients. Higher ReHo was observed in Controls in the left parietal-occipital area. Finally, ADT patients presented an increase of FC in more regions than Controls. These differences may reflect an impairment in brain functioning in ADT users.
format	article
author	Julio Plata-Bello Ana Plata-Bello Yaiza Pérez-Martín David López-Curtis Silvia Acosta-López Cristián Modroño Tomás Concepción-Massip
author_facet	Julio Plata-Bello Ana Plata-Bello Yaiza Pérez-Martín David López-Curtis Silvia Acosta-López Cristián Modroño Tomás Concepción-Massip
author_sort	Julio Plata-Bello
title	Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy
title_short	Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy
title_full	Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy
title_fullStr	Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy
title_full_unstemmed	Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy
title_sort	changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf7f30e55aec49faa3b86f690b922ff0
work_keys_str_mv	AT julioplatabello changesinrestingstatemeasuresofprostatecancerpatientsexposedtoandrogendeprivationtherapy AT anaplatabello changesinrestingstatemeasuresofprostatecancerpatientsexposedtoandrogendeprivationtherapy AT yaizaperezmartin changesinrestingstatemeasuresofprostatecancerpatientsexposedtoandrogendeprivationtherapy AT davidlopezcurtis changesinrestingstatemeasuresofprostatecancerpatientsexposedtoandrogendeprivationtherapy AT silviaacostalopez changesinrestingstatemeasuresofprostatecancerpatientsexposedtoandrogendeprivationtherapy AT cristianmodrono changesinrestingstatemeasuresofprostatecancerpatientsexposedtoandrogendeprivationtherapy AT tomasconcepcionmassip changesinrestingstatemeasuresofprostatecancerpatientsexposedtoandrogendeprivationtherapy
_version_	1718372156244492288

Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy

Ejemplares similares