Body weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort

Abstract Repeated weight fluctuation has been proposed as a potential risk factor for increasing morbidity and mortality including cancer. We aimed to investigate the association between body weight variability (BWV) and all cancer and site-specific cancer incidence and the impact of smoking on thes...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu Jin Cho, Jin Seul Kawk, Hyung-Jin Yoon, Minseon Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf81249f73ba4240b5713e9ef89debb5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf81249f73ba4240b5713e9ef89debb5
record_format	dspace
spelling	oai:doaj.org-article:bf81249f73ba4240b5713e9ef89debb52021-12-02T17:52:32ZBody weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort10.1038/s41598-021-91601-92045-2322https://doaj.org/article/bf81249f73ba4240b5713e9ef89debb52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91601-9https://doaj.org/toc/2045-2322Abstract Repeated weight fluctuation has been proposed as a potential risk factor for increasing morbidity and mortality including cancer. We aimed to investigate the association between body weight variability (BWV) and all cancer and site-specific cancer incidence and the impact of smoking on these associations. A total of 1,759,848 cancer-free male subjects who had their weight measured at least 5 times from the National Health Insurance Service-Health Screening Cohort from 2002 to 2011 were included and followed up until 2015. BWV was defined as the average absolute difference between successive values (ASV). The risk of cancer and site-specific cancer from BWV was identified using Cox proportional hazards regression analysis using hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for potential confounders including weight, and stratified analysis was also conducted according to smoking status. During the 7,015,413 person-years of follow-up, 11,494 patients (0.65%) developed new-onset cancers. BWV was associated with a higher risk of all cancers after adjustment for confounders. The highest BWV quintile group compared to the lowest had greater risks of all cancers and site-specific cancers including lung, liver, and prostate cancer (HR 1.22, 95% CI 1.15–1.30; HR 1.22, 95% CI 1.07–1.39; HR 1.46, 95% CI 1.19–1.81; HR 1.36, 95% CI 1.15–1.62, in all cancers, lung, liver and prostate cancer, respectively). Due to small number of cancer occurrence, the risk of kidney cancer was increased, but statistically insignificant (HR 1.38, 95% CI 0.91–2.10). Similar results were observed in noncurrent smokers. However, in current smokers, the risks of all cancers and only prostate cancer were significantly increased in the highest BWV quintile group (HR 1.19, 95% CI 1.09–1.31; HR 1.51, 95% CI 1.08–2.11). The risk of kidney cancer also increased in this group, although the finding was not statistically significant (HR 1.77, 95% CI 0.87–3.63) This study suggested BWV is an independent risk factor for cancer in men, especially in lung, liver, and prostate cancer, but evidence was weaker in kidney cancer. This association remained significant only in prostate cancer in current smokers.Yu Jin ChoJin Seul KawkHyung-Jin YoonMinseon ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Jin Cho Jin Seul Kawk Hyung-Jin Yoon Minseon Park Body weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort
description	Abstract Repeated weight fluctuation has been proposed as a potential risk factor for increasing morbidity and mortality including cancer. We aimed to investigate the association between body weight variability (BWV) and all cancer and site-specific cancer incidence and the impact of smoking on these associations. A total of 1,759,848 cancer-free male subjects who had their weight measured at least 5 times from the National Health Insurance Service-Health Screening Cohort from 2002 to 2011 were included and followed up until 2015. BWV was defined as the average absolute difference between successive values (ASV). The risk of cancer and site-specific cancer from BWV was identified using Cox proportional hazards regression analysis using hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for potential confounders including weight, and stratified analysis was also conducted according to smoking status. During the 7,015,413 person-years of follow-up, 11,494 patients (0.65%) developed new-onset cancers. BWV was associated with a higher risk of all cancers after adjustment for confounders. The highest BWV quintile group compared to the lowest had greater risks of all cancers and site-specific cancers including lung, liver, and prostate cancer (HR 1.22, 95% CI 1.15–1.30; HR 1.22, 95% CI 1.07–1.39; HR 1.46, 95% CI 1.19–1.81; HR 1.36, 95% CI 1.15–1.62, in all cancers, lung, liver and prostate cancer, respectively). Due to small number of cancer occurrence, the risk of kidney cancer was increased, but statistically insignificant (HR 1.38, 95% CI 0.91–2.10). Similar results were observed in noncurrent smokers. However, in current smokers, the risks of all cancers and only prostate cancer were significantly increased in the highest BWV quintile group (HR 1.19, 95% CI 1.09–1.31; HR 1.51, 95% CI 1.08–2.11). The risk of kidney cancer also increased in this group, although the finding was not statistically significant (HR 1.77, 95% CI 0.87–3.63) This study suggested BWV is an independent risk factor for cancer in men, especially in lung, liver, and prostate cancer, but evidence was weaker in kidney cancer. This association remained significant only in prostate cancer in current smokers.
format	article
author	Yu Jin Cho Jin Seul Kawk Hyung-Jin Yoon Minseon Park
author_facet	Yu Jin Cho Jin Seul Kawk Hyung-Jin Yoon Minseon Park
author_sort	Yu Jin Cho
title	Body weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort
title_short	Body weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort
title_full	Body weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort
title_fullStr	Body weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort
title_full_unstemmed	Body weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort
title_sort	body weight variability and cancer incidence in men aged 40 years and older-korean national insurance service cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf81249f73ba4240b5713e9ef89debb5
work_keys_str_mv	AT yujincho bodyweightvariabilityandcancerincidenceinmenaged40yearsandolderkoreannationalinsuranceservicecohort AT jinseulkawk bodyweightvariabilityandcancerincidenceinmenaged40yearsandolderkoreannationalinsuranceservicecohort AT hyungjinyoon bodyweightvariabilityandcancerincidenceinmenaged40yearsandolderkoreannationalinsuranceservicecohort AT minseonpark bodyweightvariabilityandcancerincidenceinmenaged40yearsandolderkoreannationalinsuranceservicecohort
_version_	1718379191624269824

Body weight variability and cancer incidence in men aged 40 years and older-Korean National Insurance Service Cohort

Ejemplares similares