Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)

Abstract Individual differences in personality are associated with variation in healthy aging. Health behaviours are often cited as the likely explanation for this association; however, an underlying biological mechanism may also exist. Accelerated leukocyte telomere shortening is implicated in mult...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	James R. Evans, Jose V. Torres-Pérez, Maria Elena Miletto Petrazzini, Riva Riley, Caroline H. Brennan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf84c6ebf06b494f8b913660361f2d32
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf84c6ebf06b494f8b913660361f2d32
record_format	dspace
spelling	oai:doaj.org-article:bf84c6ebf06b494f8b913660361f2d322021-12-02T15:23:03ZStress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)10.1038/s41598-020-79615-12045-2322https://doaj.org/article/bf84c6ebf06b494f8b913660361f2d322021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79615-1https://doaj.org/toc/2045-2322Abstract Individual differences in personality are associated with variation in healthy aging. Health behaviours are often cited as the likely explanation for this association; however, an underlying biological mechanism may also exist. Accelerated leukocyte telomere shortening is implicated in multiple age-related diseases and is associated with chronic activation of the hypothalamus–pituitary–adrenal (HPA) axis, providing a link between stress-related personality differences and adverse health outcomes. However, the effects of the HPA axis are tissue specific. Thus, leukocyte telomere length may not accurately reflect telomere length in disease-relevant tissues. Here, we examined the correlation between stress reactivity and telomere length in heart and brain tissue in young (6–9 month) and aging (18 month) zebrafish. Stress reactivity was assessed by tank diving and through gene expression. Telomere length was assessed using quantitative PCR. We show that aging zebrafish have shorter telomeres in both heart and brain. Telomere length was inversely related to stress reactivity in heart but not brain of aging individuals. These data support the hypotheses that an anxious predisposition contributes to accelerated telomere shortening in heart tissue, which may have important implications for our understanding of age-related heart disease, and that stress reactivity contributes to age-related telomere shortening in a tissue-specific manner.James R. EvansJose V. Torres-PérezMaria Elena Miletto PetrazziniRiva RileyCaroline H. BrennanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q James R. Evans Jose V. Torres-Pérez Maria Elena Miletto Petrazzini Riva Riley Caroline H. Brennan Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)
description	Abstract Individual differences in personality are associated with variation in healthy aging. Health behaviours are often cited as the likely explanation for this association; however, an underlying biological mechanism may also exist. Accelerated leukocyte telomere shortening is implicated in multiple age-related diseases and is associated with chronic activation of the hypothalamus–pituitary–adrenal (HPA) axis, providing a link between stress-related personality differences and adverse health outcomes. However, the effects of the HPA axis are tissue specific. Thus, leukocyte telomere length may not accurately reflect telomere length in disease-relevant tissues. Here, we examined the correlation between stress reactivity and telomere length in heart and brain tissue in young (6–9 month) and aging (18 month) zebrafish. Stress reactivity was assessed by tank diving and through gene expression. Telomere length was assessed using quantitative PCR. We show that aging zebrafish have shorter telomeres in both heart and brain. Telomere length was inversely related to stress reactivity in heart but not brain of aging individuals. These data support the hypotheses that an anxious predisposition contributes to accelerated telomere shortening in heart tissue, which may have important implications for our understanding of age-related heart disease, and that stress reactivity contributes to age-related telomere shortening in a tissue-specific manner.
format	article
author	James R. Evans Jose V. Torres-Pérez Maria Elena Miletto Petrazzini Riva Riley Caroline H. Brennan
author_facet	James R. Evans Jose V. Torres-Pérez Maria Elena Miletto Petrazzini Riva Riley Caroline H. Brennan
author_sort	James R. Evans
title	Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)
title_short	Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)
title_full	Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)
title_fullStr	Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)
title_full_unstemmed	Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)
title_sort	stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (danio rerio)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf84c6ebf06b494f8b913660361f2d32
work_keys_str_mv	AT jamesrevans stressreactivityelicitsatissuespecificreductionintelomerelengthinagingzebrafishdaniorerio AT josevtorresperez stressreactivityelicitsatissuespecificreductionintelomerelengthinagingzebrafishdaniorerio AT mariaelenamilettopetrazzini stressreactivityelicitsatissuespecificreductionintelomerelengthinagingzebrafishdaniorerio AT rivariley stressreactivityelicitsatissuespecificreductionintelomerelengthinagingzebrafishdaniorerio AT carolinehbrennan stressreactivityelicitsatissuespecificreductionintelomerelengthinagingzebrafishdaniorerio
_version_	1718387350817472512

Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio)

Ejemplares similares