Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells

Abstract Lung adenocarcinoma is heterogeneous and hierarchically organized, with a subpopulation of stem-like cells (CSCs) that reside at the apex of the hierarchy, in which exosomes act as important mediators by transporting specific molecules among different cell populations. Although there have b...

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Autores principales:	Hai-Tao Luo, Yuan-Yuan Zheng, Jun Tang, Li-Juan Shao, Yi-Heng Mao, Wei Yang, Xiao-Fei Yang, Yang Li, Rui-Jun Tian, Fu-Rong Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/bf853ecf67ca4e85834b4772f5f78fed
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spelling	oai:doaj.org-article:bf853ecf67ca4e85834b4772f5f78fed2021-12-02T17:41:29ZDissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells10.1038/s41525-021-00217-52056-7944https://doaj.org/article/bf853ecf67ca4e85834b4772f5f78fed2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41525-021-00217-5https://doaj.org/toc/2056-7944Abstract Lung adenocarcinoma is heterogeneous and hierarchically organized, with a subpopulation of stem-like cells (CSCs) that reside at the apex of the hierarchy, in which exosomes act as important mediators by transporting specific molecules among different cell populations. Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. Here we present a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells (LSLCs). The transcriptome analysis indicates the specific patterns of exosomal constituents, including the fragmentation of transcripts and the low-level presence of circular RNAs, and identifies multiple exosomal-enriched mRNAs and lncRNAs. Integrative analysis of transcriptome and proteome data reveals the diverse functions of exosomal-enriched RNAs and proteins, many of which are associated with tumorigenesis. Importantly, several LSLC markers we identified are highly expressed in LSLC-derived exosomes and associate with poor survival, which may serve as promising liquid biopsy biomarkers for lung adenocarcinoma diagnosis. Our study provides a resource for the future elucidation of the functions of tumor-derived exosomes and their regulatory mechanisms in mediating lung cancer development.Hai-Tao LuoYuan-Yuan ZhengJun TangLi-Juan ShaoYi-Heng MaoWei YangXiao-Fei YangYang LiRui-Jun TianFu-Rong LiNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Hai-Tao Luo Yuan-Yuan Zheng Jun Tang Li-Juan Shao Yi-Heng Mao Wei Yang Xiao-Fei Yang Yang Li Rui-Jun Tian Fu-Rong Li Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells
description	Abstract Lung adenocarcinoma is heterogeneous and hierarchically organized, with a subpopulation of stem-like cells (CSCs) that reside at the apex of the hierarchy, in which exosomes act as important mediators by transporting specific molecules among different cell populations. Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. Here we present a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells (LSLCs). The transcriptome analysis indicates the specific patterns of exosomal constituents, including the fragmentation of transcripts and the low-level presence of circular RNAs, and identifies multiple exosomal-enriched mRNAs and lncRNAs. Integrative analysis of transcriptome and proteome data reveals the diverse functions of exosomal-enriched RNAs and proteins, many of which are associated with tumorigenesis. Importantly, several LSLC markers we identified are highly expressed in LSLC-derived exosomes and associate with poor survival, which may serve as promising liquid biopsy biomarkers for lung adenocarcinoma diagnosis. Our study provides a resource for the future elucidation of the functions of tumor-derived exosomes and their regulatory mechanisms in mediating lung cancer development.
format	article
author	Hai-Tao Luo Yuan-Yuan Zheng Jun Tang Li-Juan Shao Yi-Heng Mao Wei Yang Xiao-Fei Yang Yang Li Rui-Jun Tian Fu-Rong Li
author_facet	Hai-Tao Luo Yuan-Yuan Zheng Jun Tang Li-Juan Shao Yi-Heng Mao Wei Yang Xiao-Fei Yang Yang Li Rui-Jun Tian Fu-Rong Li
author_sort	Hai-Tao Luo
title	Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells
title_short	Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells
title_full	Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells
title_fullStr	Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells
title_full_unstemmed	Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells
title_sort	dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf853ecf67ca4e85834b4772f5f78fed
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Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells

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