CTCF is a barrier for 2C-like reprogramming

Embryos at the 2-cell (2C) stage are totipotent, and overexpression of Dux transcription factor convert embryonic stem cells (ESCs) to a 2C-like state. Here the authors show that DUX-mediated 2C-like reprogramming is associated with DNA damage at CTCF sites and CTCF depletion promotes 2Clike convers...

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Autores principales:	Teresa Olbrich, Maria Vega-Sendino, Desiree Tillo, Wei Wu, Nicholas Zolnerowich, Raphael Pavani, Andy D. Tran, Catherine N. Domingo, Mariajose Franco, Marta Markiewicz-Potoczny, Gianluca Pegoraro, Peter C. FitzGerald, Michael J. Kruhlak, Eros Lazzerini-Denchi, Elphege P. Nora, André Nussenzweig, Sergio Ruiz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf8a1039f8ce4857979f039a7114f987
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spelling	oai:doaj.org-article:bf8a1039f8ce4857979f039a7114f9872021-12-02T19:06:38ZCTCF is a barrier for 2C-like reprogramming10.1038/s41467-021-25072-x2041-1723https://doaj.org/article/bf8a1039f8ce4857979f039a7114f9872021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25072-xhttps://doaj.org/toc/2041-1723Embryos at the 2-cell (2C) stage are totipotent, and overexpression of Dux transcription factor convert embryonic stem cells (ESCs) to a 2C-like state. Here the authors show that DUX-mediated 2C-like reprogramming is associated with DNA damage at CTCF sites and CTCF depletion promotes 2Clike conversion.Teresa OlbrichMaria Vega-SendinoDesiree TilloWei WuNicholas ZolnerowichRaphael PavaniAndy D. TranCatherine N. DomingoMariajose FrancoMarta Markiewicz-PotocznyGianluca PegoraroPeter C. FitzGeraldMichael J. KruhlakEros Lazzerini-DenchiElphege P. NoraAndré NussenzweigSergio RuizNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teresa Olbrich Maria Vega-Sendino Desiree Tillo Wei Wu Nicholas Zolnerowich Raphael Pavani Andy D. Tran Catherine N. Domingo Mariajose Franco Marta Markiewicz-Potoczny Gianluca Pegoraro Peter C. FitzGerald Michael J. Kruhlak Eros Lazzerini-Denchi Elphege P. Nora André Nussenzweig Sergio Ruiz CTCF is a barrier for 2C-like reprogramming
description	Embryos at the 2-cell (2C) stage are totipotent, and overexpression of Dux transcription factor convert embryonic stem cells (ESCs) to a 2C-like state. Here the authors show that DUX-mediated 2C-like reprogramming is associated with DNA damage at CTCF sites and CTCF depletion promotes 2Clike conversion.
format	article
author	Teresa Olbrich Maria Vega-Sendino Desiree Tillo Wei Wu Nicholas Zolnerowich Raphael Pavani Andy D. Tran Catherine N. Domingo Mariajose Franco Marta Markiewicz-Potoczny Gianluca Pegoraro Peter C. FitzGerald Michael J. Kruhlak Eros Lazzerini-Denchi Elphege P. Nora André Nussenzweig Sergio Ruiz
author_facet	Teresa Olbrich Maria Vega-Sendino Desiree Tillo Wei Wu Nicholas Zolnerowich Raphael Pavani Andy D. Tran Catherine N. Domingo Mariajose Franco Marta Markiewicz-Potoczny Gianluca Pegoraro Peter C. FitzGerald Michael J. Kruhlak Eros Lazzerini-Denchi Elphege P. Nora André Nussenzweig Sergio Ruiz
author_sort	Teresa Olbrich
title	CTCF is a barrier for 2C-like reprogramming
title_short	CTCF is a barrier for 2C-like reprogramming
title_full	CTCF is a barrier for 2C-like reprogramming
title_fullStr	CTCF is a barrier for 2C-like reprogramming
title_full_unstemmed	CTCF is a barrier for 2C-like reprogramming
title_sort	ctcf is a barrier for 2c-like reprogramming
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf8a1039f8ce4857979f039a7114f987
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CTCF is a barrier for 2C-like reprogramming

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