Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir

Although there have been documented Ebola virus disease outbreaks for more than 40 years, the natural reservoir host has not been identified. Recent studies provide evidence that the Angolan free-tailed bat (<i>Mops condylurus</i>), an insectivorous microbat, is a possible ebolavirus res...

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Autores principales:	Marcel Bokelmann, Uwe Vogel, Franka Debeljak, Ariane Düx, Silke Riesle-Sbarbaro, Angelika Lander, Annette Wahlbrink, Nicole Kromarek, Stuart Neil, Emmanuel Couacy-Hymann, Joseph Prescott, Andreas Kurth
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Ebola virus reservoir host bat virus replication tolerance persistent infection Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/bf8c0727e13947b5aa282c591f8380d0
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spelling	oai:doaj.org-article:bf8c0727e13947b5aa282c591f8380d02021-11-25T19:13:10ZTolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir10.3390/v131121861999-4915https://doaj.org/article/bf8c0727e13947b5aa282c591f8380d02021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2186https://doaj.org/toc/1999-4915Although there have been documented Ebola virus disease outbreaks for more than 40 years, the natural reservoir host has not been identified. Recent studies provide evidence that the Angolan free-tailed bat (<i>Mops condylurus</i>), an insectivorous microbat, is a possible ebolavirus reservoir. To investigate the potential role of this bat species in the ecology of ebolaviruses, replication, tolerance, and persistence of Ebola virus (EBOV) were investigated in 10 different primary bat cell isolates from <i>M. condylurus</i>. Varying EBOV replication kinetics corresponded to the expression levels of the integral membrane protein NPC1. All primary cells were highly tolerant to EBOV infection without cytopathic effects. The observed persistent EBOV infection for 150 days in lung primary cells, without resultant selective pressure leading to virus mutation, indicate the intrinsic ability of EBOV to persist in this bat species. These results provide further evidence for this bat species to be a likely reservoir of ebolaviruses.Marcel BokelmannUwe VogelFranka DebeljakAriane DüxSilke Riesle-SbarbaroAngelika LanderAnnette WahlbrinkNicole KromarekStuart NeilEmmanuel Couacy-HymannJoseph PrescottAndreas KurthMDPI AGarticleEbola virusreservoir hostbatvirus replicationtolerancepersistent infectionMicrobiologyQR1-502ENViruses, Vol 13, Iss 2186, p 2186 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ebola virus reservoir host bat virus replication tolerance persistent infection Microbiology QR1-502
spellingShingle	Ebola virus reservoir host bat virus replication tolerance persistent infection Microbiology QR1-502 Marcel Bokelmann Uwe Vogel Franka Debeljak Ariane Düx Silke Riesle-Sbarbaro Angelika Lander Annette Wahlbrink Nicole Kromarek Stuart Neil Emmanuel Couacy-Hymann Joseph Prescott Andreas Kurth Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir
description	Although there have been documented Ebola virus disease outbreaks for more than 40 years, the natural reservoir host has not been identified. Recent studies provide evidence that the Angolan free-tailed bat (<i>Mops condylurus</i>), an insectivorous microbat, is a possible ebolavirus reservoir. To investigate the potential role of this bat species in the ecology of ebolaviruses, replication, tolerance, and persistence of Ebola virus (EBOV) were investigated in 10 different primary bat cell isolates from <i>M. condylurus</i>. Varying EBOV replication kinetics corresponded to the expression levels of the integral membrane protein NPC1. All primary cells were highly tolerant to EBOV infection without cytopathic effects. The observed persistent EBOV infection for 150 days in lung primary cells, without resultant selective pressure leading to virus mutation, indicate the intrinsic ability of EBOV to persist in this bat species. These results provide further evidence for this bat species to be a likely reservoir of ebolaviruses.
format	article
author	Marcel Bokelmann Uwe Vogel Franka Debeljak Ariane Düx Silke Riesle-Sbarbaro Angelika Lander Annette Wahlbrink Nicole Kromarek Stuart Neil Emmanuel Couacy-Hymann Joseph Prescott Andreas Kurth
author_facet	Marcel Bokelmann Uwe Vogel Franka Debeljak Ariane Düx Silke Riesle-Sbarbaro Angelika Lander Annette Wahlbrink Nicole Kromarek Stuart Neil Emmanuel Couacy-Hymann Joseph Prescott Andreas Kurth
author_sort	Marcel Bokelmann
title	Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir
title_short	Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir
title_full	Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir
title_fullStr	Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir
title_full_unstemmed	Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir
title_sort	tolerance and persistence of ebola virus in primary cells from <i>mops condylurus</i>, a potential ebola virus reservoir
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bf8c0727e13947b5aa282c591f8380d0
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Tolerance and Persistence of Ebola Virus in Primary Cells from <i>Mops condylurus</i>, a Potential Ebola Virus Reservoir

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