Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2

IL-2 is used systemically for cancer therapy but it is associated with severe toxicity. Here, the authors design a recombinant vaccinia virus expressing membrane-bound IL-2 that shows therapeutic efficacy alone or in combination with checkpoint inhibitors in colon cancer-bearing mice.

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Autores principales:	Zuqiang Liu, Yan Ge, Haiyan Wang, Congrong Ma, Mathilde Feist, Songguang Ju, Z. Sheng Guo, David L. Bartlett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf8c62b2e7b9492694731295e94b4d6e
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spelling	oai:doaj.org-article:bf8c62b2e7b9492694731295e94b4d6e2021-12-02T17:33:04ZModifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-210.1038/s41467-018-06954-z2041-1723https://doaj.org/article/bf8c62b2e7b9492694731295e94b4d6e2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06954-zhttps://doaj.org/toc/2041-1723IL-2 is used systemically for cancer therapy but it is associated with severe toxicity. Here, the authors design a recombinant vaccinia virus expressing membrane-bound IL-2 that shows therapeutic efficacy alone or in combination with checkpoint inhibitors in colon cancer-bearing mice.Zuqiang LiuYan GeHaiyan WangCongrong MaMathilde FeistSongguang JuZ. Sheng GuoDavid L. BartlettNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zuqiang Liu Yan Ge Haiyan Wang Congrong Ma Mathilde Feist Songguang Ju Z. Sheng Guo David L. Bartlett Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2
description	IL-2 is used systemically for cancer therapy but it is associated with severe toxicity. Here, the authors design a recombinant vaccinia virus expressing membrane-bound IL-2 that shows therapeutic efficacy alone or in combination with checkpoint inhibitors in colon cancer-bearing mice.
format	article
author	Zuqiang Liu Yan Ge Haiyan Wang Congrong Ma Mathilde Feist Songguang Ju Z. Sheng Guo David L. Bartlett
author_facet	Zuqiang Liu Yan Ge Haiyan Wang Congrong Ma Mathilde Feist Songguang Ju Z. Sheng Guo David L. Bartlett
author_sort	Zuqiang Liu
title	Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2
title_short	Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2
title_full	Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2
title_fullStr	Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2
title_full_unstemmed	Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2
title_sort	modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bf8c62b2e7b9492694731295e94b4d6e
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Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2

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