Macrophages and Iron: A Special Relationship

Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the major targets of homeostatic phagocytosis by macropha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stefania Recalcati, Gaetano Cairo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	macrophage iron ferroptosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bf8ccefc79894de88786667684f97b70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf8ccefc79894de88786667684f97b70
record_format	dspace
spelling	oai:doaj.org-article:bf8ccefc79894de88786667684f97b702021-11-25T16:49:17ZMacrophages and Iron: A Special Relationship10.3390/biomedicines91115852227-9059https://doaj.org/article/bf8ccefc79894de88786667684f97b702021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1585https://doaj.org/toc/2227-9059Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the major targets of homeostatic phagocytosis by macrophages are old/damaged red blood cells. As such, macrophages play a crucial role in iron trafficking, as they recycle the large quantity of iron obtained by hemoglobin degradation. They also seem particularly adapted to handle and store amounts of iron that would be toxic to other cell types. Here, we examine the specific and peculiar iron metabolism of macrophages.Stefania RecalcatiGaetano CairoMDPI AGarticlemacrophageironferroptosisBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1585, p 1585 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrophage iron ferroptosis Biology (General) QH301-705.5
spellingShingle	macrophage iron ferroptosis Biology (General) QH301-705.5 Stefania Recalcati Gaetano Cairo Macrophages and Iron: A Special Relationship
description	Macrophages perform a variety of different biological functions and are known for their essential role in the immune response. In this context, a principal function is phagocytic clearance of pathogens, apoptotic and senescent cells. However, the major targets of homeostatic phagocytosis by macrophages are old/damaged red blood cells. As such, macrophages play a crucial role in iron trafficking, as they recycle the large quantity of iron obtained by hemoglobin degradation. They also seem particularly adapted to handle and store amounts of iron that would be toxic to other cell types. Here, we examine the specific and peculiar iron metabolism of macrophages.
format	article
author	Stefania Recalcati Gaetano Cairo
author_facet	Stefania Recalcati Gaetano Cairo
author_sort	Stefania Recalcati
title	Macrophages and Iron: A Special Relationship
title_short	Macrophages and Iron: A Special Relationship
title_full	Macrophages and Iron: A Special Relationship
title_fullStr	Macrophages and Iron: A Special Relationship
title_full_unstemmed	Macrophages and Iron: A Special Relationship
title_sort	macrophages and iron: a special relationship
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bf8ccefc79894de88786667684f97b70
work_keys_str_mv	AT stefaniarecalcati macrophagesandironaspecialrelationship AT gaetanocairo macrophagesandironaspecialrelationship
_version_	1718412919702552576

Macrophages and Iron: A Special Relationship

Ejemplares similares