Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent

A rapid and effective method is developed for selective determination of five selected acidic drugs (salicylic acid, naproxen, diclofenac, ibuprofen and mefenamic acid) in water samples by using online solid phase extraction (Online-SPE) prior to liquid chromatography diode array detector (LC-DAD) a...

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Autores principales:	Nurzaimah Zaini @ Othman, Nor Suhaila Mohamad Hanapi, Nor’ashikin Saim, Wan Nazihah Wan Ibrahim, Ahmad Lutfi Anis
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2020
Materias:	online spe-lc alginate mwcnts acidic drugs water samples Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bf8dec45a9f94b02a48049a0a2d5f014
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spelling	oai:doaj.org-article:bf8dec45a9f94b02a48049a0a2d5f0142021-12-02T13:14:06ZSelective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent1411-94202460-157810.22146/ijc.43703https://doaj.org/article/bf8dec45a9f94b02a48049a0a2d5f0142020-07-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/43703https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578A rapid and effective method is developed for selective determination of five selected acidic drugs (salicylic acid, naproxen, diclofenac, ibuprofen and mefenamic acid) in water samples by using online solid phase extraction (Online-SPE) prior to liquid chromatography diode array detector (LC-DAD) analysis. In this study, Alginate incorporated multi-walled carbon nanotubes (Alg-MWCNT) beads were prepared and utilized as solid phase extraction sorbent. Optimization of online SPE-LC operating parameters such as valve switching time, composition of acetonitrile and buffer pH was conducted using Box-Behnken Design of Response Surface Methodology (RSM) to evaluate the interactive effects of these three variables. Under the optimized conditions (valve switching time: 1.5 min, composition of acetonitrile: MSA, 60:40 and buffer pH: pH 2), the method showed good linearity (1–500 μg L−1) with coefficient of determination (R2) of 0.9971–0.9996 and low limits of detection ≤ 0.018 µg L–1. The method showed high relative recoveries in the range of 75–110% for river water and tap water samples, respectively with RSDs of ≤ 7.8 (n = 3). This method was successfully applied to the determination of acidic drugs in river and tap water samples. In addition, Alg-MWCNT sorbent offered high degree of selectivity and efficiency for online SPE-LC-DAD analysis.Nurzaimah Zaini @ OthmanNor Suhaila Mohamad HanapiNor’ashikin SaimWan Nazihah Wan IbrahimAhmad Lutfi AnisDepartment of Chemistry, Universitas Gadjah Madaarticleonline spe-lcalginatemwcntsacidic drugswater samplesChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 20, Iss 5, Pp 987-999 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	online spe-lc alginate mwcnts acidic drugs water samples Chemistry QD1-999
spellingShingle	online spe-lc alginate mwcnts acidic drugs water samples Chemistry QD1-999 Nurzaimah Zaini @ Othman Nor Suhaila Mohamad Hanapi Nor’ashikin Saim Wan Nazihah Wan Ibrahim Ahmad Lutfi Anis Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent
description	A rapid and effective method is developed for selective determination of five selected acidic drugs (salicylic acid, naproxen, diclofenac, ibuprofen and mefenamic acid) in water samples by using online solid phase extraction (Online-SPE) prior to liquid chromatography diode array detector (LC-DAD) analysis. In this study, Alginate incorporated multi-walled carbon nanotubes (Alg-MWCNT) beads were prepared and utilized as solid phase extraction sorbent. Optimization of online SPE-LC operating parameters such as valve switching time, composition of acetonitrile and buffer pH was conducted using Box-Behnken Design of Response Surface Methodology (RSM) to evaluate the interactive effects of these three variables. Under the optimized conditions (valve switching time: 1.5 min, composition of acetonitrile: MSA, 60:40 and buffer pH: pH 2), the method showed good linearity (1–500 μg L−1) with coefficient of determination (R2) of 0.9971–0.9996 and low limits of detection ≤ 0.018 µg L–1. The method showed high relative recoveries in the range of 75–110% for river water and tap water samples, respectively with RSDs of ≤ 7.8 (n = 3). This method was successfully applied to the determination of acidic drugs in river and tap water samples. In addition, Alg-MWCNT sorbent offered high degree of selectivity and efficiency for online SPE-LC-DAD analysis.
format	article
author	Nurzaimah Zaini @ Othman Nor Suhaila Mohamad Hanapi Nor’ashikin Saim Wan Nazihah Wan Ibrahim Ahmad Lutfi Anis
author_facet	Nurzaimah Zaini @ Othman Nor Suhaila Mohamad Hanapi Nor’ashikin Saim Wan Nazihah Wan Ibrahim Ahmad Lutfi Anis
author_sort	Nurzaimah Zaini @ Othman
title	Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent
title_short	Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent
title_full	Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent
title_fullStr	Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent
title_full_unstemmed	Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent
title_sort	selective determination of acidic drugs in water samples using online solid phase extraction liquid chromatography with alginate incorporated multi-walled carbon nanotubes as extraction sorbent
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/bf8dec45a9f94b02a48049a0a2d5f014
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Selective Determination of Acidic Drugs in Water Samples Using Online Solid Phase Extraction Liquid Chromatography with Alginate Incorporated Multi-Walled Carbon Nanotubes as Extraction Sorbent

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