Methodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context

Abstract This study introduces an innovative methodological approach to identify potential drivers of structuring HIV-1 transmission clustering patterns between different subpopulations in the culturally and racially/ethnically diverse context of Houston, TX, the largest city in the Southern United...

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Autores principales:	Kayo Fujimoto, Justin Bahl, Joel O. Wertheim, Natascha Del Vecchio, Joseph T. Hicks, Lambodhar Damodaran, Camden J. Hallmark, Richa Lavingia, Ricardo Mora, Michelle Carr, Biru Yang, John A. Schneider, Lu-Yu Hwang, Marlene McNeese
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf8df380a8b84fdeb376a7e578922a3c
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spelling	oai:doaj.org-article:bf8df380a8b84fdeb376a7e578922a3c2021-12-02T14:11:30ZMethodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context10.1038/s41598-021-82673-82045-2322https://doaj.org/article/bf8df380a8b84fdeb376a7e578922a3c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82673-8https://doaj.org/toc/2045-2322Abstract This study introduces an innovative methodological approach to identify potential drivers of structuring HIV-1 transmission clustering patterns between different subpopulations in the culturally and racially/ethnically diverse context of Houston, TX, the largest city in the Southern United States. Using 6332 HIV-1 pol sequences from persons newly diagnosed with HIV during the period 2010–2018, we reconstructed HIV-1 transmission clusters, using the HIV-TRAnsmission Cluster Engine (HIV-TRACE); inferred demographic and risk parameters on HIV-1 transmission dynamics by jointly estimating viral transmission rates across racial/ethnic, age, and transmission risk groups; and modeled the degree of network connectivity by using generalized estimating equations (GEE). Our results indicate that Hispanics/Latinos are most vulnerable to the structure of transmission clusters and serve as a bridge population, acting as recipients of transmissions from Whites (3.0 state changes/year) and from Blacks (2.6 state changes/year) as well as sources of transmissions to Whites (1.8 state changes/year) and to Blacks (1.2 state changes/year). There were high rates of transmission and high network connectivity between younger and older Hispanics/Latinos as well as between younger and older Blacks. Prevention and intervention efforts are needed for transmission clusters that involve younger racial/ethnic minorities, in particular Hispanic/Latino youth, to reduce onward transmission of HIV in Houston.Kayo FujimotoJustin BahlJoel O. WertheimNatascha Del VecchioJoseph T. HicksLambodhar DamodaranCamden J. HallmarkRicha LavingiaRicardo MoraMichelle CarrBiru YangJohn A. SchneiderLu-Yu HwangMarlene McNeeseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kayo Fujimoto Justin Bahl Joel O. Wertheim Natascha Del Vecchio Joseph T. Hicks Lambodhar Damodaran Camden J. Hallmark Richa Lavingia Ricardo Mora Michelle Carr Biru Yang John A. Schneider Lu-Yu Hwang Marlene McNeese Methodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context
description	Abstract This study introduces an innovative methodological approach to identify potential drivers of structuring HIV-1 transmission clustering patterns between different subpopulations in the culturally and racially/ethnically diverse context of Houston, TX, the largest city in the Southern United States. Using 6332 HIV-1 pol sequences from persons newly diagnosed with HIV during the period 2010–2018, we reconstructed HIV-1 transmission clusters, using the HIV-TRAnsmission Cluster Engine (HIV-TRACE); inferred demographic and risk parameters on HIV-1 transmission dynamics by jointly estimating viral transmission rates across racial/ethnic, age, and transmission risk groups; and modeled the degree of network connectivity by using generalized estimating equations (GEE). Our results indicate that Hispanics/Latinos are most vulnerable to the structure of transmission clusters and serve as a bridge population, acting as recipients of transmissions from Whites (3.0 state changes/year) and from Blacks (2.6 state changes/year) as well as sources of transmissions to Whites (1.8 state changes/year) and to Blacks (1.2 state changes/year). There were high rates of transmission and high network connectivity between younger and older Hispanics/Latinos as well as between younger and older Blacks. Prevention and intervention efforts are needed for transmission clusters that involve younger racial/ethnic minorities, in particular Hispanic/Latino youth, to reduce onward transmission of HIV in Houston.
format	article
author	Kayo Fujimoto Justin Bahl Joel O. Wertheim Natascha Del Vecchio Joseph T. Hicks Lambodhar Damodaran Camden J. Hallmark Richa Lavingia Ricardo Mora Michelle Carr Biru Yang John A. Schneider Lu-Yu Hwang Marlene McNeese
author_facet	Kayo Fujimoto Justin Bahl Joel O. Wertheim Natascha Del Vecchio Joseph T. Hicks Lambodhar Damodaran Camden J. Hallmark Richa Lavingia Ricardo Mora Michelle Carr Biru Yang John A. Schneider Lu-Yu Hwang Marlene McNeese
author_sort	Kayo Fujimoto
title	Methodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context
title_short	Methodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context
title_full	Methodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context
title_fullStr	Methodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context
title_full_unstemmed	Methodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context
title_sort	methodological synthesis of bayesian phylodynamics, hiv-trace, and gee: hiv-1 transmission epidemiology in a racially/ethnically diverse southern u.s. context
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf8df380a8b84fdeb376a7e578922a3c
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Methodological synthesis of Bayesian phylodynamics, HIV-TRACE, and GEE: HIV-1 transmission epidemiology in a racially/ethnically diverse Southern U.S. context

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