Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation

Vivek Pravin Dave,1 Deepika C Parmeshwarappa,1 Avantika Dogra,1 Rajeev Reddy Pappuru,1 Avinash Pathengay,2 Joveeta Joseph,3 Taraprasad Das1 1Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India; 2Retina and Uveitis Service, GMR...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dave VP, Parmeshwarappa DC, Dogra A, Pappuru RR, Pathengay A, Joseph J, Das T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	intraocular lens explantation endophthalmitis iol delayed-onset endophthalmitis low-grade endophthalmitis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/bf94b19a3bd0454686f641e76ace3e16
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf94b19a3bd0454686f641e76ace3e16
record_format	dspace
spelling	oai:doaj.org-article:bf94b19a3bd0454686f641e76ace3e162021-12-02T09:09:07ZClinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation1177-5483https://doaj.org/article/bf94b19a3bd0454686f641e76ace3e162020-02-01T00:00:00Zhttps://www.dovepress.com/clinical-presentations-and-comparative-outcomes-of-delayed-onset-low-g-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Vivek Pravin Dave,1 Deepika C Parmeshwarappa,1 Avantika Dogra,1 Rajeev Reddy Pappuru,1 Avinash Pathengay,2 Joveeta Joseph,3 Taraprasad Das1 1Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India; 2Retina and Uveitis Service, GMR Varalakshmi Campus, LV Prasad Eye Institute, Visakhapatnam, India; 3Jhaveri Microbiology Center, LV Prasad Eye Institute, Hyderabad, IndiaCorrespondence: Vivek Pravin DaveSmt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, IndiaEmail vivekoperates@yahoo.co.inPurpose: To compare the outcomes of delayed-onset low-grade endophthalmitis managed with and without intraocular lens (IOL) explantation.Setting: Tertiary eye-care research institute in southern India.Design: Retrospective comparative case series.Methods: The study included all cases of post-cataract surgery delayed-onset endophthalmitis from January 1990 to January 2019. Time to endophthalmitis, duration of symptoms, presenting visual acuity, time to IOL explantation when performed, resolution after explantation, number of intravitreal injections, and final visual acuity were compared in the IOL non-explanted and IOL explanted groups.Results: There were 115 eyes – 61 eyes in the IOL non-explant and 54 eyes in the IOL explant group. Between the two groups there was no statistically significant difference in age (58.37 ±  14.05 and 56.04 ±  14.96 years, respectively; p=0.35), vision at presentation (> 20/400 in 29.5% and 29.6% eyes, respectively; p=0.98), and the duration of follow-up (14.38 ±  16.05, median 8.5 months and 7.06 ±  3.55, median 6 months respectively; p=0.43). There was a statistically significant difference between the IOL non-explant and IOL-explant groups in the time to resolution of inflammation (92.70 ±  36.28 and 45.33± 11.2 days, respectively; p < 0.0001) and the number of intravitreal injections (4.57 ±  0.75, median 5 and 2.79± 2.11, median 2 respectively, p=0.005). Persistent/recurrent inflammation at 6 months was recorded in 18.03% and 5.55% in the IOL non-explant and IOL explant eyes, respectively (p=0.04). Favorable functional outcome was seen in 50.81% vs 68.51% in IOL non-explant and explant eyes, respectively (p=0.05).Conclusion: IOL explantation in delayed-onset endophthalmitis helps in earlier resolution of inflammation, need for lesser number of intravitreal injections and a trend towards better functional outcomes.Keywords: intraocular lens explantation, endophthalmitis, IOL, delayed-onset endophthalmitis, low-grade endophthalmitisDave VPParmeshwarappa DCDogra APappuru RRPathengay AJoseph JDas TDove Medical Pressarticleintraocular lens explantationendophthalmitisioldelayed-onset endophthalmitislow-grade endophthalmitisOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 551-555 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	intraocular lens explantation endophthalmitis iol delayed-onset endophthalmitis low-grade endophthalmitis Ophthalmology RE1-994
spellingShingle	intraocular lens explantation endophthalmitis iol delayed-onset endophthalmitis low-grade endophthalmitis Ophthalmology RE1-994 Dave VP Parmeshwarappa DC Dogra A Pappuru RR Pathengay A Joseph J Das T Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation
description	Vivek Pravin Dave,1 Deepika C Parmeshwarappa,1 Avantika Dogra,1 Rajeev Reddy Pappuru,1 Avinash Pathengay,2 Joveeta Joseph,3 Taraprasad Das1 1Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India; 2Retina and Uveitis Service, GMR Varalakshmi Campus, LV Prasad Eye Institute, Visakhapatnam, India; 3Jhaveri Microbiology Center, LV Prasad Eye Institute, Hyderabad, IndiaCorrespondence: Vivek Pravin DaveSmt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, IndiaEmail vivekoperates@yahoo.co.inPurpose: To compare the outcomes of delayed-onset low-grade endophthalmitis managed with and without intraocular lens (IOL) explantation.Setting: Tertiary eye-care research institute in southern India.Design: Retrospective comparative case series.Methods: The study included all cases of post-cataract surgery delayed-onset endophthalmitis from January 1990 to January 2019. Time to endophthalmitis, duration of symptoms, presenting visual acuity, time to IOL explantation when performed, resolution after explantation, number of intravitreal injections, and final visual acuity were compared in the IOL non-explanted and IOL explanted groups.Results: There were 115 eyes – 61 eyes in the IOL non-explant and 54 eyes in the IOL explant group. Between the two groups there was no statistically significant difference in age (58.37 ±  14.05 and 56.04 ±  14.96 years, respectively; p=0.35), vision at presentation (> 20/400 in 29.5% and 29.6% eyes, respectively; p=0.98), and the duration of follow-up (14.38 ±  16.05, median 8.5 months and 7.06 ±  3.55, median 6 months respectively; p=0.43). There was a statistically significant difference between the IOL non-explant and IOL-explant groups in the time to resolution of inflammation (92.70 ±  36.28 and 45.33± 11.2 days, respectively; p < 0.0001) and the number of intravitreal injections (4.57 ±  0.75, median 5 and 2.79± 2.11, median 2 respectively, p=0.005). Persistent/recurrent inflammation at 6 months was recorded in 18.03% and 5.55% in the IOL non-explant and IOL explant eyes, respectively (p=0.04). Favorable functional outcome was seen in 50.81% vs 68.51% in IOL non-explant and explant eyes, respectively (p=0.05).Conclusion: IOL explantation in delayed-onset endophthalmitis helps in earlier resolution of inflammation, need for lesser number of intravitreal injections and a trend towards better functional outcomes.Keywords: intraocular lens explantation, endophthalmitis, IOL, delayed-onset endophthalmitis, low-grade endophthalmitis
format	article
author	Dave VP Parmeshwarappa DC Dogra A Pappuru RR Pathengay A Joseph J Das T
author_facet	Dave VP Parmeshwarappa DC Dogra A Pappuru RR Pathengay A Joseph J Das T
author_sort	Dave VP
title	Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation
title_short	Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation
title_full	Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation
title_fullStr	Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation
title_full_unstemmed	Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation
title_sort	clinical presentations and comparative outcomes of delayed-onset low-grade endophthalmitis managed with or without intraocular lens explantation
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bf94b19a3bd0454686f641e76ace3e16
work_keys_str_mv	AT davevp clinicalpresentationsandcomparativeoutcomesofdelayedonsetlowgradeendophthalmitismanagedwithorwithoutintraocularlensexplantation AT parmeshwarappadc clinicalpresentationsandcomparativeoutcomesofdelayedonsetlowgradeendophthalmitismanagedwithorwithoutintraocularlensexplantation AT dograa clinicalpresentationsandcomparativeoutcomesofdelayedonsetlowgradeendophthalmitismanagedwithorwithoutintraocularlensexplantation AT pappururr clinicalpresentationsandcomparativeoutcomesofdelayedonsetlowgradeendophthalmitismanagedwithorwithoutintraocularlensexplantation AT pathengaya clinicalpresentationsandcomparativeoutcomesofdelayedonsetlowgradeendophthalmitismanagedwithorwithoutintraocularlensexplantation AT josephj clinicalpresentationsandcomparativeoutcomesofdelayedonsetlowgradeendophthalmitismanagedwithorwithoutintraocularlensexplantation AT dast clinicalpresentationsandcomparativeoutcomesofdelayedonsetlowgradeendophthalmitismanagedwithorwithoutintraocularlensexplantation
_version_	1718398268404137984

Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation

Ejemplares similares