Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes

Abstract The onset and worsening of some diseases are related to the variation and instability of gut microbiota. However, studies examining the personal variation of gut microbiota in detail are limited. Here, we evaluated the yearly variation of individual gut microbiota in 218 Japanese subjects a...

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Autores principales:	Ryuta Amamoto, Kazuhito Shimamoto, Sungjin Park, Hoshitaka Matsumoto, Kensuke Shimizu, Miyuki Katto, Hirokazu Tsuji, Satoshi Matsubara, Roy J. Shephard, Yukitoshi Aoyagi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf9897d54aab4541967a5a4250422a35
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spelling	oai:doaj.org-article:bf9897d54aab4541967a5a4250422a352021-12-02T17:41:27ZYearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes10.1038/s41598-021-91917-62045-2322https://doaj.org/article/bf9897d54aab4541967a5a4250422a352021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91917-6https://doaj.org/toc/2045-2322Abstract The onset and worsening of some diseases are related to the variation and instability of gut microbiota. However, studies examining the personal variation of gut microbiota in detail are limited. Here, we evaluated the yearly variation of individual gut microbiota in 218 Japanese subjects aged 66–91 years, using Jensen-Shannon distance (JSD) metrics. Approximately 9% of the subjects showed a substantial change, as their formerly predominant bacterial families were replaced over the year. These subjects consumed fermented milk products less frequently than their peers. The relationship between the intake frequencies of fermented milk products containing Lactocaseibacillus paracasei strain Shirota (LcS) and JSD values was also investigated. The intra-individual JSD of subjects ingesting LcS products ≥ 3 days/week over the past 10 years was statistically lower than the < 3 days/week group (P = 0.045). Focusing on subjects with substantial gut microbiota changes, only 1.7% of the subjects were included in the LcS intake ≥ 3 days/week group whereas 11.3% were found in the < 3 days/week group (P = 0.029). These results suggest that about one-tenth of the elderly Japanese could experience a substantial change in their gut microbiota during a 1-year period, and that the habitual intake of probiotics may stabilize their gut microbiota.Ryuta AmamotoKazuhito ShimamotoSungjin ParkHoshitaka MatsumotoKensuke ShimizuMiyuki KattoHirokazu TsujiSatoshi MatsubaraRoy J. ShephardYukitoshi AoyagiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryuta Amamoto Kazuhito Shimamoto Sungjin Park Hoshitaka Matsumoto Kensuke Shimizu Miyuki Katto Hirokazu Tsuji Satoshi Matsubara Roy J. Shephard Yukitoshi Aoyagi Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes
description	Abstract The onset and worsening of some diseases are related to the variation and instability of gut microbiota. However, studies examining the personal variation of gut microbiota in detail are limited. Here, we evaluated the yearly variation of individual gut microbiota in 218 Japanese subjects aged 66–91 years, using Jensen-Shannon distance (JSD) metrics. Approximately 9% of the subjects showed a substantial change, as their formerly predominant bacterial families were replaced over the year. These subjects consumed fermented milk products less frequently than their peers. The relationship between the intake frequencies of fermented milk products containing Lactocaseibacillus paracasei strain Shirota (LcS) and JSD values was also investigated. The intra-individual JSD of subjects ingesting LcS products ≥ 3 days/week over the past 10 years was statistically lower than the < 3 days/week group (P = 0.045). Focusing on subjects with substantial gut microbiota changes, only 1.7% of the subjects were included in the LcS intake ≥ 3 days/week group whereas 11.3% were found in the < 3 days/week group (P = 0.029). These results suggest that about one-tenth of the elderly Japanese could experience a substantial change in their gut microbiota during a 1-year period, and that the habitual intake of probiotics may stabilize their gut microbiota.
format	article
author	Ryuta Amamoto Kazuhito Shimamoto Sungjin Park Hoshitaka Matsumoto Kensuke Shimizu Miyuki Katto Hirokazu Tsuji Satoshi Matsubara Roy J. Shephard Yukitoshi Aoyagi
author_facet	Ryuta Amamoto Kazuhito Shimamoto Sungjin Park Hoshitaka Matsumoto Kensuke Shimizu Miyuki Katto Hirokazu Tsuji Satoshi Matsubara Roy J. Shephard Yukitoshi Aoyagi
author_sort	Ryuta Amamoto
title	Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes
title_short	Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes
title_full	Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes
title_fullStr	Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes
title_full_unstemmed	Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes
title_sort	yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf9897d54aab4541967a5a4250422a35
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Yearly changes in the composition of gut microbiota in the elderly, and the effect of lactobacilli intake on these changes

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