Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.

Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 de...

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Autores principales:	Marie Hennebelle, Laure Balasse, Alizée Latour, Gaelle Champeil-Potokar, Stéphanie Denis, Monique Lavialle, Pascale Gisquet-Verrier, Isabelle Denis, Sylvie Vancassel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf9c55a6e12e4be2ac6a7ddf804e9846
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spelling	oai:doaj.org-article:bf9c55a6e12e4be2ac6a7ddf804e98462021-11-18T07:10:23ZInfluence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.1932-620310.1371/journal.pone.0042142https://doaj.org/article/bf9c55a6e12e4be2ac6a7ddf804e98462012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22860066/?tool=EBIhttps://doaj.org/toc/1932-6203Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 deficient, control or omega-3 enriched diets from conception. We measured body weight, plasma corticosterone and hippocampus glucocorticoid receptors and correlated these data with emotional and depression-like behaviour assessed by their open-field (OF) activity, anxiety in the elevated-plus maze (EPM), the sucrose preference test and the startle response. We also determined their plasma and brain membrane lipid profiles by gas chromatography. Repeated restraint stress caused rats fed a control diet to lose weight. Their plasma corticosterone increased and they showed moderate behavioural changes, with increases only in grooming (OF test) and entries into the open arms (EPM). Rats fed the omega-3 enriched diet had a lower stress-induced weight loss and plasma corticosterone peak, and reduced grooming. Rats chronically lacking omega-3 fatty acid exhibited an increased startle response, a stress-induced decrease in locomotor activity and exaggerated grooming. The brain omega-3 fatty acids increased as the dietary omega-3 fatty acids increased; diets containing preformed long-chain omega-3 fatty acid were better than diets containing the precursor alpha-linolenic acid. However, the restraint stress reduced the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency was deleterious while enrichment protecting against stress.Marie HennebelleLaure BalasseAlizée LatourGaelle Champeil-PotokarStéphanie DenisMonique LaviallePascale Gisquet-VerrierIsabelle DenisSylvie VancasselPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e42142 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Hennebelle Laure Balasse Alizée Latour Gaelle Champeil-Potokar Stéphanie Denis Monique Lavialle Pascale Gisquet-Verrier Isabelle Denis Sylvie Vancassel Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.
description	Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 deficient, control or omega-3 enriched diets from conception. We measured body weight, plasma corticosterone and hippocampus glucocorticoid receptors and correlated these data with emotional and depression-like behaviour assessed by their open-field (OF) activity, anxiety in the elevated-plus maze (EPM), the sucrose preference test and the startle response. We also determined their plasma and brain membrane lipid profiles by gas chromatography. Repeated restraint stress caused rats fed a control diet to lose weight. Their plasma corticosterone increased and they showed moderate behavioural changes, with increases only in grooming (OF test) and entries into the open arms (EPM). Rats fed the omega-3 enriched diet had a lower stress-induced weight loss and plasma corticosterone peak, and reduced grooming. Rats chronically lacking omega-3 fatty acid exhibited an increased startle response, a stress-induced decrease in locomotor activity and exaggerated grooming. The brain omega-3 fatty acids increased as the dietary omega-3 fatty acids increased; diets containing preformed long-chain omega-3 fatty acid were better than diets containing the precursor alpha-linolenic acid. However, the restraint stress reduced the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency was deleterious while enrichment protecting against stress.
format	article
author	Marie Hennebelle Laure Balasse Alizée Latour Gaelle Champeil-Potokar Stéphanie Denis Monique Lavialle Pascale Gisquet-Verrier Isabelle Denis Sylvie Vancassel
author_facet	Marie Hennebelle Laure Balasse Alizée Latour Gaelle Champeil-Potokar Stéphanie Denis Monique Lavialle Pascale Gisquet-Verrier Isabelle Denis Sylvie Vancassel
author_sort	Marie Hennebelle
title	Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.
title_short	Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.
title_full	Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.
title_fullStr	Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.
title_full_unstemmed	Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.
title_sort	influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/bf9c55a6e12e4be2ac6a7ddf804e9846
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Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress.

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