Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder

Hasan Büyükaslan,1 Mehmet Asoğlu2 1Department of Emergency Medicine, Harran University Medical Faculty, Sanliurfa, Turkey; 2Psychiatry Department, Harran University Medical Faculty, Sanliurfa, TurkeyCorrespondence: Hasan BüyükaslanDepartment of Emergency Medicine,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Büyükaslan H, Asoğlu M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Conversion disorder Inflammation Hematologic tests Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bf9cf4dcf9a1450c8dcce7f5e8af38c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bf9cf4dcf9a1450c8dcce7f5e8af38c8
record_format	dspace
spelling	oai:doaj.org-article:bf9cf4dcf9a1450c8dcce7f5e8af38c82021-12-02T03:31:18ZEvaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder1178-2021https://doaj.org/article/bf9cf4dcf9a1450c8dcce7f5e8af38c82019-10-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-mean-platelet-volume-red-cell-distributed-width-and-neut-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hasan Büyükaslan,1 Mehmet Asoğlu2 1Department of Emergency Medicine, Harran University Medical Faculty, Sanliurfa, Turkey; 2Psychiatry Department, Harran University Medical Faculty, Sanliurfa, TurkeyCorrespondence: Hasan BüyükaslanDepartment of Emergency Medicine, Harran University Medical Faculty, Sanliurfa, TurkeyTel +90 530 644 6845Email hasanbuyukaslan@hotmail.comBackground: The pathophysiology of conversion disorder (CD) is still not fully established. Many psychiatric disorders are known to be associated with inflammatory processes. We aimed to compare the routine hemogram values of CD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups.Methods: This study was conducted with CD patients (n=158) and healthy controls (n=145). Routine hematological parameters were examined in each participant. Group comparisons were made with Mann–Whitney U-test and Student’s t-test. Regression analysis and receiver operating curve (ROC) analysis were also performed for the analysis of independent predictors.Results: The comparisons revealed that while neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet, neutrophil, red cell distribution width (RDW), and mean platelet volume (MPV) were significantly higher in CD group (P<0.05), lymphocyte was decreased in that group (P>0.05). Multivariate and ROC analyses showed MPV, RDW, and NLR as independent predictors (P<0.05). ROC curve showed that MPV values of 7.8 or above could predict the CD with 84% sensitivity and 85% specificity (area under curve [AUC]=0.878; 95% confidence interval [CI]: 0.817–0.939), RDW values of 11.0 or above could predict the CD with 82% sensitivity and 73% specificity (AUC=0.871; 95% CI: 0.815–0.926), and NLR values of 1.8 or above could predict the CD with 85% sensitivity and 78% specificity (AUC=0.865; 95% CI: 0.802–0.929).Conclusion: CD is related to the acute inflammatory process. MPV, RDW, and NLR can reflect this inflammation. These parameters could be used in differential diagnosis; increased RDW and MPV levels can be used as a novel marker in CD.Keywords: conversion disorder, inflammation, hematologic testsBüyükaslan HAsoğlu MDove Medical PressarticleConversion disorderInflammationHematologic testsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2879-2884 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Conversion disorder Inflammation Hematologic tests Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Conversion disorder Inflammation Hematologic tests Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Büyükaslan H Asoğlu M Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder
description	Hasan Büyükaslan,1 Mehmet Asoğlu2 1Department of Emergency Medicine, Harran University Medical Faculty, Sanliurfa, Turkey; 2Psychiatry Department, Harran University Medical Faculty, Sanliurfa, TurkeyCorrespondence: Hasan BüyükaslanDepartment of Emergency Medicine, Harran University Medical Faculty, Sanliurfa, TurkeyTel +90 530 644 6845Email hasanbuyukaslan@hotmail.comBackground: The pathophysiology of conversion disorder (CD) is still not fully established. Many psychiatric disorders are known to be associated with inflammatory processes. We aimed to compare the routine hemogram values of CD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups.Methods: This study was conducted with CD patients (n=158) and healthy controls (n=145). Routine hematological parameters were examined in each participant. Group comparisons were made with Mann–Whitney U-test and Student’s t-test. Regression analysis and receiver operating curve (ROC) analysis were also performed for the analysis of independent predictors.Results: The comparisons revealed that while neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet, neutrophil, red cell distribution width (RDW), and mean platelet volume (MPV) were significantly higher in CD group (P<0.05), lymphocyte was decreased in that group (P>0.05). Multivariate and ROC analyses showed MPV, RDW, and NLR as independent predictors (P<0.05). ROC curve showed that MPV values of 7.8 or above could predict the CD with 84% sensitivity and 85% specificity (area under curve [AUC]=0.878; 95% confidence interval [CI]: 0.817–0.939), RDW values of 11.0 or above could predict the CD with 82% sensitivity and 73% specificity (AUC=0.871; 95% CI: 0.815–0.926), and NLR values of 1.8 or above could predict the CD with 85% sensitivity and 78% specificity (AUC=0.865; 95% CI: 0.802–0.929).Conclusion: CD is related to the acute inflammatory process. MPV, RDW, and NLR can reflect this inflammation. These parameters could be used in differential diagnosis; increased RDW and MPV levels can be used as a novel marker in CD.Keywords: conversion disorder, inflammation, hematologic tests
format	article
author	Büyükaslan H Asoğlu M
author_facet	Büyükaslan H Asoğlu M
author_sort	Büyükaslan H
title	Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder
title_short	Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder
title_full	Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder
title_fullStr	Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder
title_full_unstemmed	Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder
title_sort	evaluation of mean platelet volume, red cell distributed width and neutrophil to lymphocyte ratio in conversion disorder
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/bf9cf4dcf9a1450c8dcce7f5e8af38c8
work_keys_str_mv	AT buyukaslanh evaluationofmeanplateletvolumeredcelldistributedwidthandneutrophiltolymphocyteratioinconversiondisorder AT asoglum evaluationofmeanplateletvolumeredcelldistributedwidthandneutrophiltolymphocyteratioinconversiondisorder
_version_	1718401756108423168

Evaluation Of Mean Platelet Volume, Red Cell Distributed Width And Neutrophil To Lymphocyte Ratio In Conversion Disorder

Ejemplares similares