Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer

Vitamin D has been associated with risk, development, and progression of cancer. However, the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of this study is to evaluate the association between the gene polymorphisms involved in the metabolic pathway of v...

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Autores principales:	Laura Elena Pineda Lancheros, Cristina Pérez Ramírez, Almudena Sánchez Martín, José María Gálvez Navas, Fernando Martínez Martínez, María del Carmen Ramírez Tortosa, Alberto Jiménez Morales
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamin D metabolism survival non-small-cell lung cancer single nucleotide polymorphisms <i>CYP27B1</i> <i>CYP24A1</i> Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/bf9fa9de08f24e2aa9dd67acdbddf3e6
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spelling	oai:doaj.org-article:bf9fa9de08f24e2aa9dd67acdbddf3e62021-11-25T18:34:00ZImpact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer10.3390/nu131137832072-6643https://doaj.org/article/bf9fa9de08f24e2aa9dd67acdbddf3e62021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3783https://doaj.org/toc/2072-6643Vitamin D has been associated with risk, development, and progression of cancer. However, the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of this study is to evaluate the association between the gene polymorphisms involved in the metabolic pathway of vitamin D and survival in patients with non-small-cell lung cancer (NSCLC). The study was designed as an observational cohort which included 194 Caucasians patients from southern Spain with NSCLC. Real-time polymerase chain reaction was used to analyze the following polymorphisms: <i>CYP27B1</i> rs4646536, rs3782130, and rs10877012; <i>CYP24A1</i> rs6068816 and rs4809957; <i>GC</i> rs7041; <i>CYP2R1</i> rs10741657; <i>VDR</i> rs1544410 (BsmI), rs11568820 (Cdx-2), rs2228570 (FokI), rs7975232 (ApaI), and rs731236 (TaqI). Progression-free survival (PFS) and overall survival were assessed. Cox regression showed that rs4646536 was associated with PFS in the general population (<i>p</i> = 0.0233) and in the non-resected NSCLC subgroup (<i>p</i> = 0.0233). In the resected NSCLC subgroup, rs11568820 was associated with OS (<i>p</i> = 0.0129) and rs7041 with PFS (<i>p</i> = 0.0447). In the non-resected NSCLC subgroup, rs6068816 was associated with PFS (<i>p</i> = 0.0048) and OS (<i>p</i> = 0.0089) and rs731236 and rs7975232 were associated with OS (<i>p</i> = 0.0005) and PFS (<i>p</i> = 0.0002), respectively. The other polymorphisms showed no effect on the results. The rs4646536, rs6068816, rs7041, rs11568820, rs731236, and rs7975232 polymorphisms are associated with survival in NSCLC and may have a substantial role as prognostic markers of the disease.Laura Elena Pineda LancherosCristina Pérez RamírezAlmudena Sánchez MartínJosé María Gálvez NavasFernando Martínez MartínezMaría del Carmen Ramírez TortosaAlberto Jiménez MoralesMDPI AGarticlevitamin D metabolismsurvivalnon-small-cell lung cancersingle nucleotide polymorphisms<i>CYP27B1</i><i>CYP24A1</i>Nutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3783, p 3783 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D metabolism survival non-small-cell lung cancer single nucleotide polymorphisms <i>CYP27B1</i> <i>CYP24A1</i> Nutrition. Foods and food supply TX341-641
spellingShingle	vitamin D metabolism survival non-small-cell lung cancer single nucleotide polymorphisms <i>CYP27B1</i> <i>CYP24A1</i> Nutrition. Foods and food supply TX341-641 Laura Elena Pineda Lancheros Cristina Pérez Ramírez Almudena Sánchez Martín José María Gálvez Navas Fernando Martínez Martínez María del Carmen Ramírez Tortosa Alberto Jiménez Morales Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer
description	Vitamin D has been associated with risk, development, and progression of cancer. However, the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of this study is to evaluate the association between the gene polymorphisms involved in the metabolic pathway of vitamin D and survival in patients with non-small-cell lung cancer (NSCLC). The study was designed as an observational cohort which included 194 Caucasians patients from southern Spain with NSCLC. Real-time polymerase chain reaction was used to analyze the following polymorphisms: <i>CYP27B1</i> rs4646536, rs3782130, and rs10877012; <i>CYP24A1</i> rs6068816 and rs4809957; <i>GC</i> rs7041; <i>CYP2R1</i> rs10741657; <i>VDR</i> rs1544410 (BsmI), rs11568820 (Cdx-2), rs2228570 (FokI), rs7975232 (ApaI), and rs731236 (TaqI). Progression-free survival (PFS) and overall survival were assessed. Cox regression showed that rs4646536 was associated with PFS in the general population (<i>p</i> = 0.0233) and in the non-resected NSCLC subgroup (<i>p</i> = 0.0233). In the resected NSCLC subgroup, rs11568820 was associated with OS (<i>p</i> = 0.0129) and rs7041 with PFS (<i>p</i> = 0.0447). In the non-resected NSCLC subgroup, rs6068816 was associated with PFS (<i>p</i> = 0.0048) and OS (<i>p</i> = 0.0089) and rs731236 and rs7975232 were associated with OS (<i>p</i> = 0.0005) and PFS (<i>p</i> = 0.0002), respectively. The other polymorphisms showed no effect on the results. The rs4646536, rs6068816, rs7041, rs11568820, rs731236, and rs7975232 polymorphisms are associated with survival in NSCLC and may have a substantial role as prognostic markers of the disease.
format	article
author	Laura Elena Pineda Lancheros Cristina Pérez Ramírez Almudena Sánchez Martín José María Gálvez Navas Fernando Martínez Martínez María del Carmen Ramírez Tortosa Alberto Jiménez Morales
author_facet	Laura Elena Pineda Lancheros Cristina Pérez Ramírez Almudena Sánchez Martín José María Gálvez Navas Fernando Martínez Martínez María del Carmen Ramírez Tortosa Alberto Jiménez Morales
author_sort	Laura Elena Pineda Lancheros
title	Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer
title_short	Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer
title_full	Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer
title_fullStr	Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer
title_full_unstemmed	Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer
title_sort	impact of genetic polymorphisms on the metabolic pathway of vitamin d and survival in non-small cell lung cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bf9fa9de08f24e2aa9dd67acdbddf3e6
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Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer

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