In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

Abstract Fungal infections are among the most difficult diseases to manage in humans. Eukaryotic fungal pathogens share many similarities with their host cells, which impairs the development of antifungal compounds. Therefore, it is desirable to harness the pharmaceutical potential of medicinal plan...

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Autores principales:	Daisy Savarirajan, V. M. Ramesh, Arunachalam Muthaiyan
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Antifungal activity Dermatophytic fungi Plant extracts Dermatophytosis Cassia occidentalis Asparagus racemosus Chemistry QD1-999 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/bf9ff410a8764d41bcda3ddfa77a23f5
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spelling	oai:doaj.org-article:bf9ff410a8764d41bcda3ddfa77a23f52021-11-07T12:07:14ZIn vitro antidermatophytic activity of bioactive compounds from selected medicinal plants10.1186/s40543-021-00304-32093-3371https://doaj.org/article/bf9ff410a8764d41bcda3ddfa77a23f52021-11-01T00:00:00Zhttps://doi.org/10.1186/s40543-021-00304-3https://doaj.org/toc/2093-3371Abstract Fungal infections are among the most difficult diseases to manage in humans. Eukaryotic fungal pathogens share many similarities with their host cells, which impairs the development of antifungal compounds. Therefore, it is desirable to harness the pharmaceutical potential of medicinal plants for antifungal drug discovery. In this study, the antifungal activity of sixteen plant extracts was investigated against selected dermatophytic fungi. Of the sixteen plants, the cladode (leaf) of Asparagus racemosus, and seed extract of Cassia occidentalis showed antifungal activity against Microsporum gypseum, Microsporum nanum, Trichophyton mentagrophytes and Trichophyton terrestre. The plant antifungal compounds were located by direct bioassay against Cladosporium herbarum. IR and NMR spectrometry analyses of these compounds identified the presence of saponin (in A. racemosus) and hydroxy anthraquinone (in C. occidentalis) in these antifungal compounds. The antidermatophytic activity of plant anthraquinone and saponins with reports of little or no hemolytic activity, makes these compounds ideal for alternative antifungal therapy and warrants further in-depth investigation in vivo.Daisy SavarirajanV. M. RameshArunachalam MuthaiyanSpringerOpenarticleAntifungal activityDermatophytic fungiPlant extractsDermatophytosisCassia occidentalisAsparagus racemosusChemistryQD1-999Analytical chemistryQD71-142ENJournal of Analytical Science and Technology, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antifungal activity Dermatophytic fungi Plant extracts Dermatophytosis Cassia occidentalis Asparagus racemosus Chemistry QD1-999 Analytical chemistry QD71-142
spellingShingle	Antifungal activity Dermatophytic fungi Plant extracts Dermatophytosis Cassia occidentalis Asparagus racemosus Chemistry QD1-999 Analytical chemistry QD71-142 Daisy Savarirajan V. M. Ramesh Arunachalam Muthaiyan In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants
description	Abstract Fungal infections are among the most difficult diseases to manage in humans. Eukaryotic fungal pathogens share many similarities with their host cells, which impairs the development of antifungal compounds. Therefore, it is desirable to harness the pharmaceutical potential of medicinal plants for antifungal drug discovery. In this study, the antifungal activity of sixteen plant extracts was investigated against selected dermatophytic fungi. Of the sixteen plants, the cladode (leaf) of Asparagus racemosus, and seed extract of Cassia occidentalis showed antifungal activity against Microsporum gypseum, Microsporum nanum, Trichophyton mentagrophytes and Trichophyton terrestre. The plant antifungal compounds were located by direct bioassay against Cladosporium herbarum. IR and NMR spectrometry analyses of these compounds identified the presence of saponin (in A. racemosus) and hydroxy anthraquinone (in C. occidentalis) in these antifungal compounds. The antidermatophytic activity of plant anthraquinone and saponins with reports of little or no hemolytic activity, makes these compounds ideal for alternative antifungal therapy and warrants further in-depth investigation in vivo.
format	article
author	Daisy Savarirajan V. M. Ramesh Arunachalam Muthaiyan
author_facet	Daisy Savarirajan V. M. Ramesh Arunachalam Muthaiyan
author_sort	Daisy Savarirajan
title	In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants
title_short	In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants
title_full	In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants
title_fullStr	In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants
title_full_unstemmed	In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants
title_sort	in vitro antidermatophytic activity of bioactive compounds from selected medicinal plants
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/bf9ff410a8764d41bcda3ddfa77a23f5
work_keys_str_mv	AT daisysavarirajan invitroantidermatophyticactivityofbioactivecompoundsfromselectedmedicinalplants AT vmramesh invitroantidermatophyticactivityofbioactivecompoundsfromselectedmedicinalplants AT arunachalammuthaiyan invitroantidermatophyticactivityofbioactivecompoundsfromselectedmedicinalplants
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In vitro antidermatophytic activity of bioactive compounds from selected medicinal plants

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