Stem cell therapy in autism: recent insights
Dario Siniscalco,1 Suresh Kannan,2 Neomar Semprún-Hernández,3 Adrien A Eshraghi,4 Anna Lisa Brigida,5 Nicola Antonucci6 1Department of Experimental Medicine, University of Campania, Napoli, Italy; 2Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2018
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| Acceso en línea: | https://doaj.org/article/bfa4f72ec27843129bfc3184792dbf56 |
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| Sumario: | Dario Siniscalco,1 Suresh Kannan,2 Neomar Semprún-Hernández,3 Adrien A Eshraghi,4 Anna Lisa Brigida,5 Nicola Antonucci6 1Department of Experimental Medicine, University of Campania, Napoli, Italy; 2Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India; 3Research Division, Autism Immunology Unit of Maracaibo, Catedra libre de Autismo, Universidad del Zulia, Maracaibo, Venezuela; 4Department of Otolaryngology, Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine, Miami, FL, USA; 5Italian Group for Studying Autism – GISA, Brescia, Italy; 6Biomedical Centre for Autism Research and Treatment, Bari, Italy Abstract: Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed. Keywords: autism spectrum disorder, stem cell, cell therapy, immune dysfunction |
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