Stem cell therapy in autism: recent insights
Dario Siniscalco,1 Suresh Kannan,2 Neomar Semprún-Hernández,3 Adrien A Eshraghi,4 Anna Lisa Brigida,5 Nicola Antonucci6 1Department of Experimental Medicine, University of Campania, Napoli, Italy; 2Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education...
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Dove Medical Press
2018
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oai:doaj.org-article:bfa4f72ec27843129bfc3184792dbf562021-12-02T07:43:51ZStem cell therapy in autism: recent insights1178-6957https://doaj.org/article/bfa4f72ec27843129bfc3184792dbf562018-10-01T00:00:00Zhttps://www.dovepress.com/stem-cell-therapy-in-autism-recent-insights-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Dario Siniscalco,1 Suresh Kannan,2 Neomar Semprún-Hernández,3 Adrien A Eshraghi,4 Anna Lisa Brigida,5 Nicola Antonucci6 1Department of Experimental Medicine, University of Campania, Napoli, Italy; 2Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India; 3Research Division, Autism Immunology Unit of Maracaibo, Catedra libre de Autismo, Universidad del Zulia, Maracaibo, Venezuela; 4Department of Otolaryngology, Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine, Miami, FL, USA; 5Italian Group for Studying Autism – GISA, Brescia, Italy; 6Biomedical Centre for Autism Research and Treatment, Bari, Italy Abstract: Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed. Keywords: autism spectrum disorder, stem cell, cell therapy, immune dysfunction Siniscalco DKannan SSemprún-Hernández NEshraghi AABrigida ALAntonucci NDove Medical Pressarticleautism spectrum disorderstem cellcell therapyimmune dysfunction.CytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 11, Pp 55-67 (2018) |
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DOAJ |
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EN |
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autism spectrum disorder stem cell cell therapy immune dysfunction. Cytology QH573-671 |
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autism spectrum disorder stem cell cell therapy immune dysfunction. Cytology QH573-671 Siniscalco D Kannan S Semprún-Hernández N Eshraghi AA Brigida AL Antonucci N Stem cell therapy in autism: recent insights |
| description |
Dario Siniscalco,1 Suresh Kannan,2 Neomar Semprún-Hernández,3 Adrien A Eshraghi,4 Anna Lisa Brigida,5 Nicola Antonucci6 1Department of Experimental Medicine, University of Campania, Napoli, Italy; 2Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India; 3Research Division, Autism Immunology Unit of Maracaibo, Catedra libre de Autismo, Universidad del Zulia, Maracaibo, Venezuela; 4Department of Otolaryngology, Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine, Miami, FL, USA; 5Italian Group for Studying Autism – GISA, Brescia, Italy; 6Biomedical Centre for Autism Research and Treatment, Bari, Italy Abstract: Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed. Keywords: autism spectrum disorder, stem cell, cell therapy, immune dysfunction |
| format |
article |
| author |
Siniscalco D Kannan S Semprún-Hernández N Eshraghi AA Brigida AL Antonucci N |
| author_facet |
Siniscalco D Kannan S Semprún-Hernández N Eshraghi AA Brigida AL Antonucci N |
| author_sort |
Siniscalco D |
| title |
Stem cell therapy in autism: recent insights |
| title_short |
Stem cell therapy in autism: recent insights |
| title_full |
Stem cell therapy in autism: recent insights |
| title_fullStr |
Stem cell therapy in autism: recent insights |
| title_full_unstemmed |
Stem cell therapy in autism: recent insights |
| title_sort |
stem cell therapy in autism: recent insights |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/bfa4f72ec27843129bfc3184792dbf56 |
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