SPARC Aggravates Blood-Brain Barrier Disruption via Integrin αVβ3/MAPKs/MMP-9 Signaling Pathway after Subarachnoid Hemorrhage

Blood-brain barrier (BBB) disruption is a common and critical pathology following subarachnoid hemorrhage (SAH). We investigated the BBB disruption property of secreted protein acidic and rich in cysteine (SPARC) after SAH. A total of 197 rats underwent endovascular perforation to induce SAH or sham...

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Bibliographic Details
Main Authors: Takeshi Okada, Hidenori Suzuki, Zachary D. Travis, Orhan Altay, Jiping Tang, John H. Zhang
Format: article
Language:EN
Published: Hindawi Limited 2021
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Online Access:https://doaj.org/article/bfa51321fecc4473ad2db28f7f5fa266
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