The landscape of chromothripsis across adult cancer types

The landscape of chromothripsis across adult cancer types

The shattering of chromosomes is a dramatic early event in tumourigenesis and is termed chromothripsis. Here, the authors examine chromothripsis across 28 tumour types and show that 49% of cancers exhibit features of chromothripsis.

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Autores principales: Natalia Voronina, John K. L. Wong, Daniel Hübschmann, Mario Hlevnjak, Sebastian Uhrig, Christoph E. Heilig, Peter Horak, Simon Kreutzfeldt, Andreas Mock, Albrecht Stenzinger, Barbara Hutter, Martina Fröhlich, Benedikt Brors, Arne Jahn, Barbara Klink, Laura Gieldon, Lina Sieverling, Lars Feuerbach, Priya Chudasama, Katja Beck, Matthias Kroiss, Christoph Heining, Lino Möhrmann, Andrea Fischer, Evelin Schröck, Hanno Glimm, Marc Zapatka, Peter Lichter, Stefan Fröhling, Aurélie Ernst
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bfa7b0c2c5f44dfead7de201eaa3b1b2
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spelling oai:doaj.org-article:bfa7b0c2c5f44dfead7de201eaa3b1b22021-12-02T14:40:28ZThe landscape of chromothripsis across adult cancer types10.1038/s41467-020-16134-72041-1723https://doaj.org/article/bfa7b0c2c5f44dfead7de201eaa3b1b22020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16134-7https://doaj.org/toc/2041-1723The shattering of chromosomes is a dramatic early event in tumourigenesis and is termed chromothripsis. Here, the authors examine chromothripsis across 28 tumour types and show that 49% of cancers exhibit features of chromothripsis.Natalia VoroninaJohn K. L. WongDaniel HübschmannMario HlevnjakSebastian UhrigChristoph E. HeiligPeter HorakSimon KreutzfeldtAndreas MockAlbrecht StenzingerBarbara HutterMartina FröhlichBenedikt BrorsArne JahnBarbara KlinkLaura GieldonLina SieverlingLars FeuerbachPriya ChudasamaKatja BeckMatthias KroissChristoph HeiningLino MöhrmannAndrea FischerEvelin SchröckHanno GlimmMarc ZapatkaPeter LichterStefan FröhlingAurélie ErnstNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Natalia Voronina
John K. L. Wong
Daniel Hübschmann
Mario Hlevnjak
Sebastian Uhrig
Christoph E. Heilig
Peter Horak
Simon Kreutzfeldt
Andreas Mock
Albrecht Stenzinger
Barbara Hutter
Martina Fröhlich
Benedikt Brors
Arne Jahn
Barbara Klink
Laura Gieldon
Lina Sieverling
Lars Feuerbach
Priya Chudasama
Katja Beck
Matthias Kroiss
Christoph Heining
Lino Möhrmann
Andrea Fischer
Evelin Schröck
Hanno Glimm
Marc Zapatka
Peter Lichter
Stefan Fröhling
Aurélie Ernst
The landscape of chromothripsis across adult cancer types
description The shattering of chromosomes is a dramatic early event in tumourigenesis and is termed chromothripsis. Here, the authors examine chromothripsis across 28 tumour types and show that 49% of cancers exhibit features of chromothripsis.
format article
author Natalia Voronina
John K. L. Wong
Daniel Hübschmann
Mario Hlevnjak
Sebastian Uhrig
Christoph E. Heilig
Peter Horak
Simon Kreutzfeldt
Andreas Mock
Albrecht Stenzinger
Barbara Hutter
Martina Fröhlich
Benedikt Brors
Arne Jahn
Barbara Klink
Laura Gieldon
Lina Sieverling
Lars Feuerbach
Priya Chudasama
Katja Beck
Matthias Kroiss
Christoph Heining
Lino Möhrmann
Andrea Fischer
Evelin Schröck
Hanno Glimm
Marc Zapatka
Peter Lichter
Stefan Fröhling
Aurélie Ernst
author_facet Natalia Voronina
John K. L. Wong
Daniel Hübschmann
Mario Hlevnjak
Sebastian Uhrig
Christoph E. Heilig
Peter Horak
Simon Kreutzfeldt
Andreas Mock
Albrecht Stenzinger
Barbara Hutter
Martina Fröhlich
Benedikt Brors
Arne Jahn
Barbara Klink
Laura Gieldon
Lina Sieverling
Lars Feuerbach
Priya Chudasama
Katja Beck
Matthias Kroiss
Christoph Heining
Lino Möhrmann
Andrea Fischer
Evelin Schröck
Hanno Glimm
Marc Zapatka
Peter Lichter
Stefan Fröhling
Aurélie Ernst
author_sort Natalia Voronina
title The landscape of chromothripsis across adult cancer types
title_short The landscape of chromothripsis across adult cancer types
title_full The landscape of chromothripsis across adult cancer types
title_fullStr The landscape of chromothripsis across adult cancer types
title_full_unstemmed The landscape of chromothripsis across adult cancer types
title_sort landscape of chromothripsis across adult cancer types
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/bfa7b0c2c5f44dfead7de201eaa3b1b2
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