Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery

Abstract Background Glioma is one of the deadliest human cancers. Although many therapeutic strategies for glioma have been explored, these strategies are seldom used in the clinic. The challenges facing the treatment of glioma not only involve the development of chemotherapeutic drugs and immunothe...

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Autores principales:	Wenyan Hao, Yuexin Cui, Yueyue Fan, Mengyu Chen, Guobao Yang, Yuli Wang, Meiyan Yang, Zhiping Li, Wei Gong, Yang Yang, Chunsheng Gao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Glioma Blood–brain barrier Biomimetic nanosuspensions Chemotherapy Immunotherapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/bfaa27664be04457b661bbf87d68f7f0
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spelling	oai:doaj.org-article:bfaa27664be04457b661bbf87d68f7f02021-11-21T12:29:38ZHybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery10.1186/s12951-021-01110-01477-3155https://doaj.org/article/bfaa27664be04457b661bbf87d68f7f02021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01110-0https://doaj.org/toc/1477-3155Abstract Background Glioma is one of the deadliest human cancers. Although many therapeutic strategies for glioma have been explored, these strategies are seldom used in the clinic. The challenges facing the treatment of glioma not only involve the development of chemotherapeutic drugs and immunotherapeutic agents, but also the lack of a powerful platform that could deliver these two moieties to the targeted sites. Herein, we developed chemoimmunotherapy delivery vehicles based on C6 cell membranes and DC membranes to create hybrid membrane-coated DTX nanosuspensions (DNS-[C6&DC]m). Results Results demonstrated successful hybrid membrane fusion and nanosuspension functionalization, and DNS-[C6&DC]m could be used for different modes of anti-glioma therapy. For drug delivery, membrane coating could be applied to target the source cancer cells via a homotypic-targeting mechanism of the C6 cell membrane. For cancer immunotherapy, biomimetic nanosuspension enabled an immune response based on the professional antigen-presenting characteristic of the dendritic cell membrane (DCm), which carry the full array of cancer cell membrane antigens and facilitate the uptake of membrane-bound tumor antigens for efficient presentation and downstream immune n. Conclusion DNS-[C6&DC]m is a multifunctional biomimetic nano-drug delivery system with the potential to treat gliomas through tumor-targeted drug delivery combined with immunotherapy, thereby presenting a promising approach that may be utilized for multiple modes of cancer therapy. Graphical AbstractWenyan HaoYuexin CuiYueyue FanMengyu ChenGuobao YangYuli WangMeiyan YangZhiping LiWei GongYang YangChunsheng GaoBMCarticleGliomaBlood–brain barrierBiomimetic nanosuspensionsChemotherapyImmunotherapyBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-24 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glioma Blood–brain barrier Biomimetic nanosuspensions Chemotherapy Immunotherapy Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Glioma Blood–brain barrier Biomimetic nanosuspensions Chemotherapy Immunotherapy Biotechnology TP248.13-248.65 Medical technology R855-855.5 Wenyan Hao Yuexin Cui Yueyue Fan Mengyu Chen Guobao Yang Yuli Wang Meiyan Yang Zhiping Li Wei Gong Yang Yang Chunsheng Gao Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery
description	Abstract Background Glioma is one of the deadliest human cancers. Although many therapeutic strategies for glioma have been explored, these strategies are seldom used in the clinic. The challenges facing the treatment of glioma not only involve the development of chemotherapeutic drugs and immunotherapeutic agents, but also the lack of a powerful platform that could deliver these two moieties to the targeted sites. Herein, we developed chemoimmunotherapy delivery vehicles based on C6 cell membranes and DC membranes to create hybrid membrane-coated DTX nanosuspensions (DNS-[C6&DC]m). Results Results demonstrated successful hybrid membrane fusion and nanosuspension functionalization, and DNS-[C6&DC]m could be used for different modes of anti-glioma therapy. For drug delivery, membrane coating could be applied to target the source cancer cells via a homotypic-targeting mechanism of the C6 cell membrane. For cancer immunotherapy, biomimetic nanosuspension enabled an immune response based on the professional antigen-presenting characteristic of the dendritic cell membrane (DCm), which carry the full array of cancer cell membrane antigens and facilitate the uptake of membrane-bound tumor antigens for efficient presentation and downstream immune n. Conclusion DNS-[C6&DC]m is a multifunctional biomimetic nano-drug delivery system with the potential to treat gliomas through tumor-targeted drug delivery combined with immunotherapy, thereby presenting a promising approach that may be utilized for multiple modes of cancer therapy. Graphical Abstract
format	article
author	Wenyan Hao Yuexin Cui Yueyue Fan Mengyu Chen Guobao Yang Yuli Wang Meiyan Yang Zhiping Li Wei Gong Yang Yang Chunsheng Gao
author_facet	Wenyan Hao Yuexin Cui Yueyue Fan Mengyu Chen Guobao Yang Yuli Wang Meiyan Yang Zhiping Li Wei Gong Yang Yang Chunsheng Gao
author_sort	Wenyan Hao
title	Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery
title_short	Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery
title_full	Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery
title_fullStr	Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery
title_full_unstemmed	Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery
title_sort	hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery
publisher	BMC
publishDate	2021
url	https://doaj.org/article/bfaa27664be04457b661bbf87d68f7f0
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Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery

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