The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.

Previous studies have shown that high total homocysteine levels are associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI). In this study, we test the relationship between cognitive function and total homocysteine levels in healthy subjects (Global Dementia Rating, CDR = 0...

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Autores principales:	Ahmed A Moustafa, Doaa H Hewedi, Abeer M Eissa, Catherine E Myers, Hisham A Sadek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bfb28a3d18d64fdda7f6bfc0dfb7b010
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spelling	oai:doaj.org-article:bfb28a3d18d64fdda7f6bfc0dfb7b0102021-11-18T08:13:38ZThe relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.1932-620310.1371/journal.pone.0046496https://doaj.org/article/bfb28a3d18d64fdda7f6bfc0dfb7b0102012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029537/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Previous studies have shown that high total homocysteine levels are associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI). In this study, we test the relationship between cognitive function and total homocysteine levels in healthy subjects (Global Dementia Rating, CDR = 0) and individuals with MCI (CDR = 0.5). We have used a cognitive task that tests learning and generalization of rules, processes that have been previously shown to rely on the integrity of the striatal and hippocampal regions, respectively. We found that total homocysteine levels are higher in MCI individuals than in healthy controls. Unlike what we expected, we found no difference between MCI subjects and healthy controls in learning and generalization. We conducted further analysis after diving MCI subjects in two groups, depending on their Global Deterioration Scale (GDS) scores: individuals with very mild cognitive decline (vMCD, GDS = 2) and mild cognitive decline (MCD, GDS = 3). There was no difference among the two MCI and healthy control groups in learning performance. However, we found that individuals with MCD make more generalization errors than healthy controls and individuals with vMCD. We found no difference in the number of generalization errors between healthy controls and MCI individuals with vMCD. In addition, interestingly, we found that total homocysteine levels correlate positively with generalization errors, but not with learning errors. Our results are in agreement with prior results showing a link between hippocampal function, generalization performance, and total homocysteine levels. Importantly, our study is perhaps among the first to test the relationship between learning (and generalization) of rules and homocysteine levels in healthy controls and individuals with MCI.Ahmed A MoustafaDoaa H HewediAbeer M EissaCatherine E MyersHisham A SadekPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e46496 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ahmed A Moustafa Doaa H Hewedi Abeer M Eissa Catherine E Myers Hisham A Sadek The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.
description	Previous studies have shown that high total homocysteine levels are associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI). In this study, we test the relationship between cognitive function and total homocysteine levels in healthy subjects (Global Dementia Rating, CDR = 0) and individuals with MCI (CDR = 0.5). We have used a cognitive task that tests learning and generalization of rules, processes that have been previously shown to rely on the integrity of the striatal and hippocampal regions, respectively. We found that total homocysteine levels are higher in MCI individuals than in healthy controls. Unlike what we expected, we found no difference between MCI subjects and healthy controls in learning and generalization. We conducted further analysis after diving MCI subjects in two groups, depending on their Global Deterioration Scale (GDS) scores: individuals with very mild cognitive decline (vMCD, GDS = 2) and mild cognitive decline (MCD, GDS = 3). There was no difference among the two MCI and healthy control groups in learning performance. However, we found that individuals with MCD make more generalization errors than healthy controls and individuals with vMCD. We found no difference in the number of generalization errors between healthy controls and MCI individuals with vMCD. In addition, interestingly, we found that total homocysteine levels correlate positively with generalization errors, but not with learning errors. Our results are in agreement with prior results showing a link between hippocampal function, generalization performance, and total homocysteine levels. Importantly, our study is perhaps among the first to test the relationship between learning (and generalization) of rules and homocysteine levels in healthy controls and individuals with MCI.
format	article
author	Ahmed A Moustafa Doaa H Hewedi Abeer M Eissa Catherine E Myers Hisham A Sadek
author_facet	Ahmed A Moustafa Doaa H Hewedi Abeer M Eissa Catherine E Myers Hisham A Sadek
author_sort	Ahmed A Moustafa
title	The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.
title_short	The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.
title_full	The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.
title_fullStr	The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.
title_full_unstemmed	The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.
title_sort	relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/bfb28a3d18d64fdda7f6bfc0dfb7b010
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The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment.

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