Precision therapeutic targeting of human cancer cell motility
In this study, the authors identify and validate a halogen-substituted isoflavanone able to inhibit prostate cancer cell motility, invasion and metastasis in vitro and in vivo. They demonstrate its ability to selectively inhibit activation of client proteins that stimulate cell motility.
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| Lenguaje: | EN |
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/bfb4cee65d69447bbe13390df2a07b87 |
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oai:doaj.org-article:bfb4cee65d69447bbe13390df2a07b872021-12-02T15:34:42ZPrecision therapeutic targeting of human cancer cell motility10.1038/s41467-018-04465-52041-1723https://doaj.org/article/bfb4cee65d69447bbe13390df2a07b872018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04465-5https://doaj.org/toc/2041-1723In this study, the authors identify and validate a halogen-substituted isoflavanone able to inhibit prostate cancer cell motility, invasion and metastasis in vitro and in vivo. They demonstrate its ability to selectively inhibit activation of client proteins that stimulate cell motility.Li XuRyan GordonRebecca FarmerAbhinandan PattanayakAndrew BinkowskiXiaoke HuangMichael AvramSankar KrishnaEric VollJanet PaveseJuan ChavezJames BruceAndrew MazarAntoinette NibbsWayne AndersonLin LiBorko JovanovicSean PruellMatias ValsecchiGiulio FranciaRick BetoriKarl ScheidtRaymond BerganNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Li Xu Ryan Gordon Rebecca Farmer Abhinandan Pattanayak Andrew Binkowski Xiaoke Huang Michael Avram Sankar Krishna Eric Voll Janet Pavese Juan Chavez James Bruce Andrew Mazar Antoinette Nibbs Wayne Anderson Lin Li Borko Jovanovic Sean Pruell Matias Valsecchi Giulio Francia Rick Betori Karl Scheidt Raymond Bergan Precision therapeutic targeting of human cancer cell motility |
| description |
In this study, the authors identify and validate a halogen-substituted isoflavanone able to inhibit prostate cancer cell motility, invasion and metastasis in vitro and in vivo. They demonstrate its ability to selectively inhibit activation of client proteins that stimulate cell motility. |
| format |
article |
| author |
Li Xu Ryan Gordon Rebecca Farmer Abhinandan Pattanayak Andrew Binkowski Xiaoke Huang Michael Avram Sankar Krishna Eric Voll Janet Pavese Juan Chavez James Bruce Andrew Mazar Antoinette Nibbs Wayne Anderson Lin Li Borko Jovanovic Sean Pruell Matias Valsecchi Giulio Francia Rick Betori Karl Scheidt Raymond Bergan |
| author_facet |
Li Xu Ryan Gordon Rebecca Farmer Abhinandan Pattanayak Andrew Binkowski Xiaoke Huang Michael Avram Sankar Krishna Eric Voll Janet Pavese Juan Chavez James Bruce Andrew Mazar Antoinette Nibbs Wayne Anderson Lin Li Borko Jovanovic Sean Pruell Matias Valsecchi Giulio Francia Rick Betori Karl Scheidt Raymond Bergan |
| author_sort |
Li Xu |
| title |
Precision therapeutic targeting of human cancer cell motility |
| title_short |
Precision therapeutic targeting of human cancer cell motility |
| title_full |
Precision therapeutic targeting of human cancer cell motility |
| title_fullStr |
Precision therapeutic targeting of human cancer cell motility |
| title_full_unstemmed |
Precision therapeutic targeting of human cancer cell motility |
| title_sort |
precision therapeutic targeting of human cancer cell motility |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/bfb4cee65d69447bbe13390df2a07b87 |
| work_keys_str_mv |
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1718386804119306240 |