Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

TP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.

Guardado en:
Detalles Bibliográficos
Autores principales: Qipan Deng, Hui Hu, Xinfang Yu, Shuanglin Liu, Lei Wang, Weiqun Chen, Chi Zhang, Zhaoyang Zeng, Ya Cao, Zijun Y. Xu-Monette, Ling Li, Mingzhi Zhang, Steven Rosenfeld, Shideng Bao, Eric Hsi, Ken H. Young, Zhongxin Lu, Yong Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/bfb5d0e480864011bab4f76558e15b11
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:TP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.

Ejemplares similares