Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

TP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.

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Autores principales:	Qipan Deng, Hui Hu, Xinfang Yu, Shuanglin Liu, Lei Wang, Weiqun Chen, Chi Zhang, Zhaoyang Zeng, Ya Cao, Zijun Y. Xu-Monette, Ling Li, Mingzhi Zhang, Steven Rosenfeld, Shideng Bao, Eric Hsi, Ken H. Young, Zhongxin Lu, Yong Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bfb5d0e480864011bab4f76558e15b11
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spelling	oai:doaj.org-article:bfb5d0e480864011bab4f76558e15b112021-12-02T14:38:43ZTissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant10.1038/s41467-019-13002-x2041-1723https://doaj.org/article/bfb5d0e480864011bab4f76558e15b112019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13002-xhttps://doaj.org/toc/2041-1723TP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.Qipan DengHui HuXinfang YuShuanglin LiuLei WangWeiqun ChenChi ZhangZhaoyang ZengYa CaoZijun Y. Xu-MonetteLing LiMingzhi ZhangSteven RosenfeldShideng BaoEric HsiKen H. YoungZhongxin LuYong LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qipan Deng Hui Hu Xinfang Yu Shuanglin Liu Lei Wang Weiqun Chen Chi Zhang Zhaoyang Zeng Ya Cao Zijun Y. Xu-Monette Ling Li Mingzhi Zhang Steven Rosenfeld Shideng Bao Eric Hsi Ken H. Young Zhongxin Lu Yong Li Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
description	TP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.
format	article
author	Qipan Deng Hui Hu Xinfang Yu Shuanglin Liu Lei Wang Weiqun Chen Chi Zhang Zhaoyang Zeng Ya Cao Zijun Y. Xu-Monette Ling Li Mingzhi Zhang Steven Rosenfeld Shideng Bao Eric Hsi Ken H. Young Zhongxin Lu Yong Li
author_facet	Qipan Deng Hui Hu Xinfang Yu Shuanglin Liu Lei Wang Weiqun Chen Chi Zhang Zhaoyang Zeng Ya Cao Zijun Y. Xu-Monette Ling Li Mingzhi Zhang Steven Rosenfeld Shideng Bao Eric Hsi Ken H. Young Zhongxin Lu Yong Li
author_sort	Qipan Deng
title	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_short	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_full	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_fullStr	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_full_unstemmed	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_sort	tissue-specific microrna expression alters cancer susceptibility conferred by a tp53 noncoding variant
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bfb5d0e480864011bab4f76558e15b11
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Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

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