β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration

CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration – two key aspects for localizing peripheral leukocytes to sites of inflammation. Differential expression of CD11d induces difference...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eoin N. Blythe, Lynne C. Weaver, Arthur Brown, Gregory A. Dekaban
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	beta 2 integrin CD11d CD18 leukocyte migration extravasation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bfb9f475bb24426ab5d5e0bfa18eb9c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bfb9f475bb24426ab5d5e0bfa18eb9c6
record_format	dspace
spelling	oai:doaj.org-article:bfb9f475bb24426ab5d5e0bfa18eb9c62021-11-08T06:47:38Zβ2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration1664-322410.3389/fimmu.2021.775447https://doaj.org/article/bfb9f475bb24426ab5d5e0bfa18eb9c62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.775447/fullhttps://doaj.org/toc/1664-3224CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration – two key aspects for localizing peripheral leukocytes to sites of inflammation. Differential expression of CD11d induces differences in monocyte/macrophage mesenchymal migration including impacts on macrophage sub-set migration. The participation of CD11d/CD18 in leukocyte localization during atherosclerosis and following neurotrauma has sparked interest in the development of CD11d-targeted therapeutic agents. Whereas the adhesive properties of CD11d have undergone investigation, the signalling pathways induced by ligand binding remain largely undefined. Underlining each adhesive and signalling function, CD11d is under unique transcriptional control and expressed on a sub-set of predominately tissue-differentiated innate leukocytes. The following review is the first to capture the nearly three decades of CD11d research and discusses the emerging role of CD11d in leukocyte migration and retention during the progression of a staged immune response.Eoin N. BlytheEoin N. BlytheLynne C. WeaverLynne C. WeaverArthur BrownArthur BrownGregory A. DekabanGregory A. DekabanFrontiers Media S.A.articlebeta 2 integrinCD11dCD18leukocytemigrationextravasationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	beta 2 integrin CD11d CD18 leukocyte migration extravasation Immunologic diseases. Allergy RC581-607
spellingShingle	beta 2 integrin CD11d CD18 leukocyte migration extravasation Immunologic diseases. Allergy RC581-607 Eoin N. Blythe Eoin N. Blythe Lynne C. Weaver Lynne C. Weaver Arthur Brown Arthur Brown Gregory A. Dekaban Gregory A. Dekaban β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
description	CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration – two key aspects for localizing peripheral leukocytes to sites of inflammation. Differential expression of CD11d induces differences in monocyte/macrophage mesenchymal migration including impacts on macrophage sub-set migration. The participation of CD11d/CD18 in leukocyte localization during atherosclerosis and following neurotrauma has sparked interest in the development of CD11d-targeted therapeutic agents. Whereas the adhesive properties of CD11d have undergone investigation, the signalling pathways induced by ligand binding remain largely undefined. Underlining each adhesive and signalling function, CD11d is under unique transcriptional control and expressed on a sub-set of predominately tissue-differentiated innate leukocytes. The following review is the first to capture the nearly three decades of CD11d research and discusses the emerging role of CD11d in leukocyte migration and retention during the progression of a staged immune response.
format	article
author	Eoin N. Blythe Eoin N. Blythe Lynne C. Weaver Lynne C. Weaver Arthur Brown Arthur Brown Gregory A. Dekaban Gregory A. Dekaban
author_facet	Eoin N. Blythe Eoin N. Blythe Lynne C. Weaver Lynne C. Weaver Arthur Brown Arthur Brown Gregory A. Dekaban Gregory A. Dekaban
author_sort	Eoin N. Blythe
title	β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
title_short	β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
title_full	β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
title_fullStr	β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
title_full_unstemmed	β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration
title_sort	β2 integrin cd11d/cd18: from expression to an emerging role in staged leukocyte migration
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bfb9f475bb24426ab5d5e0bfa18eb9c6
work_keys_str_mv	AT eoinnblythe b2integrincd11dcd18fromexpressiontoanemergingroleinstagedleukocytemigration AT eoinnblythe b2integrincd11dcd18fromexpressiontoanemergingroleinstagedleukocytemigration AT lynnecweaver b2integrincd11dcd18fromexpressiontoanemergingroleinstagedleukocytemigration AT lynnecweaver b2integrincd11dcd18fromexpressiontoanemergingroleinstagedleukocytemigration AT arthurbrown b2integrincd11dcd18fromexpressiontoanemergingroleinstagedleukocytemigration AT arthurbrown b2integrincd11dcd18fromexpressiontoanemergingroleinstagedleukocytemigration AT gregoryadekaban b2integrincd11dcd18fromexpressiontoanemergingroleinstagedleukocytemigration AT gregoryadekaban b2integrincd11dcd18fromexpressiontoanemergingroleinstagedleukocytemigration
_version_	1718442941947576320

β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration

Ejemplares similares