IL-10: A possible immunobiological component of positive mental health in refugees

Objective: As the number of refugees continues to rise, there is growing concern about the impact from trauma exposures on their mental health. However, there is a limited understanding of possible biological mechanisms contributing to the substantial inter-individual differences in trauma-related o...

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Autores principales:	Sarah A. Keaton, Judy Arnetz, Hikmet Jamil, Abir Dhalimi, Paul M. Stemmer, Douglas M. Ruden, Jolin Yamin, Eric Achtyes, LeAnn Smart, Lena Brundin, Bengt B. Arnetz
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	IL-10 Refugees Mental health Energy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990
Acceso en línea:	https://doaj.org/article/bfbbef593d654f6abb75579e02927f70
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spelling	oai:doaj.org-article:bfbbef593d654f6abb75579e02927f702021-11-20T05:14:29ZIL-10: A possible immunobiological component of positive mental health in refugees2666-497610.1016/j.cpnec.2021.100097https://doaj.org/article/bfbbef593d654f6abb75579e02927f702021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666497621000710https://doaj.org/toc/2666-4976Objective: As the number of refugees continues to rise, there is growing concern about the impact from trauma exposures on their mental health. However, there is a limited understanding of possible biological mechanisms contributing to the substantial inter-individual differences in trauma-related outcomes, especially as it relates to positive mental health. Only sparse work has focused on the biology of positive mental health, including energy and sleep, in trauma-exposed persons. In this study, we analyzed cytokines in blood from newly arrived refugees with differential trauma exposures in relationship to self-reported energy, as a key marker of positive mental health. Methods: Within the first month of arrival in the USA, 64 refugees from Iraq and Syria were interviewed. Refugees completed the clinical DSM-IV PTSD-Checklist Civilian Version (PCL-C), the Beck Anxiety Inventory (BAI), and the Hospital Anxiety and Depression Scale (HADS). Ten psychiatrically healthy non-refugee persons were used as healthy controls to compare levels of cytokines. Blood samples were collected at the time of the interview and subsequently analyzed for IL-1β, IL-6, IL-8, IL-10, and TNF-α concentrations. Results: Energy correlated positively with current concentration ability and sleep quality, and negatively with stress, PCL-C, BAI and HADS scores (Spearman correlations, all p<0.05). Refugees had lower levels of IL-10 compared to controls (p<0.05). IL-10 levels in refugees correlated with higher energy levels (p<0.01). Conclusions: Results suggest that self-reported energy is a key component of positive mental health in newly arrived traumatized refugees. Additionally, the anti-inflammatory cytokine IL-10 could be a marker of, or causally associated with positive mental health. A better understanding of the balance between pro- and anti-inflammatory states in highly traumatized individuals has the potential to create more targeted and effective treatments with implications for long-term health outcomes.Sarah A. KeatonJudy ArnetzHikmet JamilAbir DhalimiPaul M. StemmerDouglas M. RudenJolin YaminEric AchtyesLeAnn SmartLena BrundinBengt B. ArnetzElsevierarticleIL-10RefugeesMental healthEnergyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571PsychologyBF1-990ENComprehensive Psychoneuroendocrinology, Vol 8, Iss , Pp 100097- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IL-10 Refugees Mental health Energy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990
spellingShingle	IL-10 Refugees Mental health Energy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990 Sarah A. Keaton Judy Arnetz Hikmet Jamil Abir Dhalimi Paul M. Stemmer Douglas M. Ruden Jolin Yamin Eric Achtyes LeAnn Smart Lena Brundin Bengt B. Arnetz IL-10: A possible immunobiological component of positive mental health in refugees
description	Objective: As the number of refugees continues to rise, there is growing concern about the impact from trauma exposures on their mental health. However, there is a limited understanding of possible biological mechanisms contributing to the substantial inter-individual differences in trauma-related outcomes, especially as it relates to positive mental health. Only sparse work has focused on the biology of positive mental health, including energy and sleep, in trauma-exposed persons. In this study, we analyzed cytokines in blood from newly arrived refugees with differential trauma exposures in relationship to self-reported energy, as a key marker of positive mental health. Methods: Within the first month of arrival in the USA, 64 refugees from Iraq and Syria were interviewed. Refugees completed the clinical DSM-IV PTSD-Checklist Civilian Version (PCL-C), the Beck Anxiety Inventory (BAI), and the Hospital Anxiety and Depression Scale (HADS). Ten psychiatrically healthy non-refugee persons were used as healthy controls to compare levels of cytokines. Blood samples were collected at the time of the interview and subsequently analyzed for IL-1β, IL-6, IL-8, IL-10, and TNF-α concentrations. Results: Energy correlated positively with current concentration ability and sleep quality, and negatively with stress, PCL-C, BAI and HADS scores (Spearman correlations, all p<0.05). Refugees had lower levels of IL-10 compared to controls (p<0.05). IL-10 levels in refugees correlated with higher energy levels (p<0.01). Conclusions: Results suggest that self-reported energy is a key component of positive mental health in newly arrived traumatized refugees. Additionally, the anti-inflammatory cytokine IL-10 could be a marker of, or causally associated with positive mental health. A better understanding of the balance between pro- and anti-inflammatory states in highly traumatized individuals has the potential to create more targeted and effective treatments with implications for long-term health outcomes.
format	article
author	Sarah A. Keaton Judy Arnetz Hikmet Jamil Abir Dhalimi Paul M. Stemmer Douglas M. Ruden Jolin Yamin Eric Achtyes LeAnn Smart Lena Brundin Bengt B. Arnetz
author_facet	Sarah A. Keaton Judy Arnetz Hikmet Jamil Abir Dhalimi Paul M. Stemmer Douglas M. Ruden Jolin Yamin Eric Achtyes LeAnn Smart Lena Brundin Bengt B. Arnetz
author_sort	Sarah A. Keaton
title	IL-10: A possible immunobiological component of positive mental health in refugees
title_short	IL-10: A possible immunobiological component of positive mental health in refugees
title_full	IL-10: A possible immunobiological component of positive mental health in refugees
title_fullStr	IL-10: A possible immunobiological component of positive mental health in refugees
title_full_unstemmed	IL-10: A possible immunobiological component of positive mental health in refugees
title_sort	il-10: a possible immunobiological component of positive mental health in refugees
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/bfbbef593d654f6abb75579e02927f70
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IL-10: A possible immunobiological component of positive mental health in refugees

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