4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage

γ-Glutamyltranspeptidases in gram-positive bacteria are not involved in glutathione metabolism, as their counterparts in eukaryotes and gram-negative bacteria. Here, the authors show that in Actinobacteria they catalyse the unusual cleavage of a C–C bond for the biosynthesis of non-proteinogenic ami...

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Autores principales:	Guannan Zhong, Qunfei Zhao, Qinglin Zhang, Wen Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bfc5f45a329b4c6db7aadf06898ed40a
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spelling	oai:doaj.org-article:bfc5f45a329b4c6db7aadf06898ed40a2021-12-02T16:51:47Z4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage10.1038/ncomms161092041-1723https://doaj.org/article/bfc5f45a329b4c6db7aadf06898ed40a2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16109https://doaj.org/toc/2041-1723γ-Glutamyltranspeptidases in gram-positive bacteria are not involved in glutathione metabolism, as their counterparts in eukaryotes and gram-negative bacteria. Here, the authors show that in Actinobacteria they catalyse the unusual cleavage of a C–C bond for the biosynthesis of non-proteinogenic amino acids.Guannan ZhongQunfei ZhaoQinglin ZhangWen LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guannan Zhong Qunfei Zhao Qinglin Zhang Wen Liu 4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage
description	γ-Glutamyltranspeptidases in gram-positive bacteria are not involved in glutathione metabolism, as their counterparts in eukaryotes and gram-negative bacteria. Here, the authors show that in Actinobacteria they catalyse the unusual cleavage of a C–C bond for the biosynthesis of non-proteinogenic amino acids.
format	article
author	Guannan Zhong Qunfei Zhao Qinglin Zhang Wen Liu
author_facet	Guannan Zhong Qunfei Zhao Qinglin Zhang Wen Liu
author_sort	Guannan Zhong
title	4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage
title_short	4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage
title_full	4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage
title_fullStr	4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage
title_full_unstemmed	4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage
title_sort	4-alkyl-l-(dehydro)proline biosynthesis in actinobacteria involves n-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for c-c bond cleavage
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bfc5f45a329b4c6db7aadf06898ed40a
work_keys_str_mv	AT guannanzhong 4alkylldehydroprolinebiosynthesisinactinobacteriainvolvesnterminalnucleophilehydrolaseactivityofgglutamyltranspeptidasehomologforccbondcleavage AT qunfeizhao 4alkylldehydroprolinebiosynthesisinactinobacteriainvolvesnterminalnucleophilehydrolaseactivityofgglutamyltranspeptidasehomologforccbondcleavage AT qinglinzhang 4alkylldehydroprolinebiosynthesisinactinobacteriainvolvesnterminalnucleophilehydrolaseactivityofgglutamyltranspeptidasehomologforccbondcleavage AT wenliu 4alkylldehydroprolinebiosynthesisinactinobacteriainvolvesnterminalnucleophilehydrolaseactivityofgglutamyltranspeptidasehomologforccbondcleavage
_version_	1718382940967141376

4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage

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