Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network

Abstract Degeneration of the substantia innominata (SI) is significantly correlated with cognitive performance in Parkinson’s disease (PD). We examined functional and structural patterns of SI degeneration in drug-naïve PD patients according to the duration of parkinsonism before mild cognitive impa...

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Main Authors:	Injoong Kim, Na-Young Shin, Yunjin Bak, Phil Hyu Lee, Seung-Koo Lee, Soo Mee Lim
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/bfc7220c5f0d448f90eff9a5dd81f486
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spelling	oai:doaj.org-article:bfc7220c5f0d448f90eff9a5dd81f4862021-12-02T12:31:49ZEarly-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network10.1038/s41598-017-02420-w2045-2322https://doaj.org/article/bfc7220c5f0d448f90eff9a5dd81f4862017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02420-whttps://doaj.org/toc/2045-2322Abstract Degeneration of the substantia innominata (SI) is significantly correlated with cognitive performance in Parkinson’s disease (PD). We examined functional and structural patterns of SI degeneration in drug-naïve PD patients according to the duration of parkinsonism before mild cognitive impairment (MCI) diagnosis. Twenty PD patients with a shorter duration (PD-MCI-SD, <1 year), 18 patients with a longer duration (PD-MCI-LD, ≥1 year), and 29 patients with intact cognition (PD-IC) were included. Seed-based resting-state functional connectivity (rsFC) analysis using bilateral SI seed and region-of-interest-based volumetric analysis were performed. Compared to PD-IC, the collapsed PD-MCI group showed altered rsFC in the right frontal and bilateral parietal areas. PD-MCI-SD showed rsFC alteration in broader frontal and parietal areas compared to the other groups. Decreased rsFC in the right frontal area was also significantly correlated with shorter disease duration. No significant SI volume change was found between the groups. Altered rsFC between the SI and the frontal and parietal areas might be relevant to cognitive dysfunction in PD. Decreased rsFC between the SI and frontal area might be associated with early-onset MCI, suggesting that cholinergic deficits in the frontal brain areas might play an important role in the acceleration of cognitive decline in PD.Injoong KimNa-Young ShinYunjin BakPhil Hyu LeeSeung-Koo LeeSoo Mee LimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Injoong Kim Na-Young Shin Yunjin Bak Phil Hyu Lee Seung-Koo Lee Soo Mee Lim Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network
description	Abstract Degeneration of the substantia innominata (SI) is significantly correlated with cognitive performance in Parkinson’s disease (PD). We examined functional and structural patterns of SI degeneration in drug-naïve PD patients according to the duration of parkinsonism before mild cognitive impairment (MCI) diagnosis. Twenty PD patients with a shorter duration (PD-MCI-SD, <1 year), 18 patients with a longer duration (PD-MCI-LD, ≥1 year), and 29 patients with intact cognition (PD-IC) were included. Seed-based resting-state functional connectivity (rsFC) analysis using bilateral SI seed and region-of-interest-based volumetric analysis were performed. Compared to PD-IC, the collapsed PD-MCI group showed altered rsFC in the right frontal and bilateral parietal areas. PD-MCI-SD showed rsFC alteration in broader frontal and parietal areas compared to the other groups. Decreased rsFC in the right frontal area was also significantly correlated with shorter disease duration. No significant SI volume change was found between the groups. Altered rsFC between the SI and the frontal and parietal areas might be relevant to cognitive dysfunction in PD. Decreased rsFC between the SI and frontal area might be associated with early-onset MCI, suggesting that cholinergic deficits in the frontal brain areas might play an important role in the acceleration of cognitive decline in PD.
format	article
author	Injoong Kim Na-Young Shin Yunjin Bak Phil Hyu Lee Seung-Koo Lee Soo Mee Lim
author_facet	Injoong Kim Na-Young Shin Yunjin Bak Phil Hyu Lee Seung-Koo Lee Soo Mee Lim
author_sort	Injoong Kim
title	Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network
title_short	Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network
title_full	Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network
title_fullStr	Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network
title_full_unstemmed	Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network
title_sort	early-onset mild cognitive impairment in parkinson’s disease: altered corticopetal cholinergic network
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bfc7220c5f0d448f90eff9a5dd81f486
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Early-onset mild cognitive impairment in Parkinson’s disease: Altered corticopetal cholinergic network

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