A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms.

A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms.

Ketamine is an NMDA receptor antagonist commonly used to maintain general anesthesia. At anesthetic doses, ketamine causes high power gamma (25-50 Hz) oscillations alternating with slow-delta (0.1-4 Hz) oscillations. These dynamics are readily observed in local field potentials (LFPs) of non-human p...

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Bibliographic Details
Main Authors: Indie C Garwood, Sourish Chakravarty, Jacob Donoghue, Meredith Mahnke, Pegah Kahali, Shubham Chamadia, Oluwaseun Akeju, Earl K Miller, Emery N Brown
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/bfc86645d7444bfca1f6c927345da53f
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