Codon pair optimization (CPO): a software tool for synthetic gene design based on codon pair bias to improve the expression of recombinant proteins in Pichia pastoris
Abstract Background Codon optimization is a common method to improve protein expression levels in Pichia pastoris and the current strategy is to replace rare codons with preferred codons to match the codon usage bias. However, codon-pair contexts have a profound effect on translation efficiency by i...
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| Auteurs principaux: | , , , , , , |
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| Format: | article |
| Langue: | EN |
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BMC
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/bfca9fcb1ebe40f795be5736a7ce732f |
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