FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that triggers permanent cell cycle arrest and full senesce...

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Autores principales:	Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer, Elsa Logarinho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bfcab92a173641ca9b7e59b64b8285c9
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spelling	oai:doaj.org-article:bfcab92a173641ca9b7e59b64b8285c92021-12-02T17:31:43ZFoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence10.1038/s41467-018-05258-62041-1723https://doaj.org/article/bfcab92a173641ca9b7e59b64b8285c92018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05258-6https://doaj.org/toc/2041-1723Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that triggers permanent cell cycle arrest and full senescence.Joana Catarina MacedoSara VazBjorn BakkerRui RibeiroPetra Lammigje BakkerJose Miguel EscandellMiguel Godinho FerreiraRené MedemaFloris FoijerElsa LogarinhoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joana Catarina Macedo Sara Vaz Bjorn Bakker Rui Ribeiro Petra Lammigje Bakker Jose Miguel Escandell Miguel Godinho Ferreira René Medema Floris Foijer Elsa Logarinho FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
description	Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that triggers permanent cell cycle arrest and full senescence.
format	article
author	Joana Catarina Macedo Sara Vaz Bjorn Bakker Rui Ribeiro Petra Lammigje Bakker Jose Miguel Escandell Miguel Godinho Ferreira René Medema Floris Foijer Elsa Logarinho
author_facet	Joana Catarina Macedo Sara Vaz Bjorn Bakker Rui Ribeiro Petra Lammigje Bakker Jose Miguel Escandell Miguel Godinho Ferreira René Medema Floris Foijer Elsa Logarinho
author_sort	Joana Catarina Macedo
title	FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
title_short	FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
title_full	FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
title_fullStr	FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
title_full_unstemmed	FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
title_sort	foxm1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bfcab92a173641ca9b7e59b64b8285c9
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FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

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