Phenotypic analysis of catastrophic childhood epilepsy genes

Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assays. Their study provides a useful resource for the...

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Autores principales:	Aliesha Griffin, Colleen Carpenter, Jing Liu, Rosalia Paterno, Brian Grone, Kyla Hamling, Maia Moog, Matthew T. Dinday, Francisco Figueroa, Mana Anvar, Chinwendu Ononuju, Tony Qu, Scott C. Baraban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bfcda728977044beb624cc6204edc73f
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spelling	oai:doaj.org-article:bfcda728977044beb624cc6204edc73f2021-12-02T15:02:56ZPhenotypic analysis of catastrophic childhood epilepsy genes10.1038/s42003-021-02221-y2399-3642https://doaj.org/article/bfcda728977044beb624cc6204edc73f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02221-yhttps://doaj.org/toc/2399-3642Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assays. Their study provides a useful resource for the future functional analysis and/or identification of potential anti-epileptic therapies.Aliesha GriffinColleen CarpenterJing LiuRosalia PaternoBrian GroneKyla HamlingMaia MoogMatthew T. DindayFrancisco FigueroaMana AnvarChinwendu OnonujuTony QuScott C. BarabanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Aliesha Griffin Colleen Carpenter Jing Liu Rosalia Paterno Brian Grone Kyla Hamling Maia Moog Matthew T. Dinday Francisco Figueroa Mana Anvar Chinwendu Ononuju Tony Qu Scott C. Baraban Phenotypic analysis of catastrophic childhood epilepsy genes
description	Griffin et al used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing childhood epilepsies for which they evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assays. Their study provides a useful resource for the future functional analysis and/or identification of potential anti-epileptic therapies.
format	article
author	Aliesha Griffin Colleen Carpenter Jing Liu Rosalia Paterno Brian Grone Kyla Hamling Maia Moog Matthew T. Dinday Francisco Figueroa Mana Anvar Chinwendu Ononuju Tony Qu Scott C. Baraban
author_facet	Aliesha Griffin Colleen Carpenter Jing Liu Rosalia Paterno Brian Grone Kyla Hamling Maia Moog Matthew T. Dinday Francisco Figueroa Mana Anvar Chinwendu Ononuju Tony Qu Scott C. Baraban
author_sort	Aliesha Griffin
title	Phenotypic analysis of catastrophic childhood epilepsy genes
title_short	Phenotypic analysis of catastrophic childhood epilepsy genes
title_full	Phenotypic analysis of catastrophic childhood epilepsy genes
title_fullStr	Phenotypic analysis of catastrophic childhood epilepsy genes
title_full_unstemmed	Phenotypic analysis of catastrophic childhood epilepsy genes
title_sort	phenotypic analysis of catastrophic childhood epilepsy genes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bfcda728977044beb624cc6204edc73f
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Phenotypic analysis of catastrophic childhood epilepsy genes

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