IMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS

The study aimed to compare subset composition of peripheral blood lymphocytes in 40 newborns at different gestation periods, complicated by a verified prenatal infection (1st group), or with hypoxic brain damage (2nd group), using a flow cytometry technique. It was found that activated CD14+HLA-DR+...

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Autores principales:	T. I. Dolgikh, M. V. Shelyov, E. V. Nesterenko, T. N. Belkova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	newborns prenatal infections flow cytometry lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bfcdc641c6e544e6958b8754f87d2907
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spelling	oai:doaj.org-article:bfcdc641c6e544e6958b8754f87d29072021-11-18T08:03:39ZIMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS1563-06252313-741X10.15789/1563-0625-2010-4-5-417-420https://doaj.org/article/bfcdc641c6e544e6958b8754f87d29072014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/287https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study aimed to compare subset composition of peripheral blood lymphocytes in 40 newborns at different gestation periods, complicated by a verified prenatal infection (1st group), or with hypoxic brain damage (2nd group), using a flow cytometry technique. It was found that activated CD14+HLA-DR+ monocytes were 2,3-fold more common in the infants from the 1st group, and representation of CD5+CD19+ B1 lymphocytes (a «forbidden» clone) was 1,8-fold higher than in 2nd group. Among pre-term babies from the 1st group, the lymphocytes with CD3+CD16+/CD56+, CD3+CD95+ and CD5+CD19+ phenotype were registered more often, than in full-term infants (resp., 5, 11, and 2 times higher). These data argue for involvement of compensatory defense immune mechanisms under the conditions of increased antigenic load, being more pronounced in pre-term infants.T. I. DolgikhM. V. ShelyovE. V. NesterenkoT. N. BelkovaSPb RAACIarticlenewbornsprenatal infectionsflow cytometrylymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 417-420 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	newborns prenatal infections flow cytometry lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	newborns prenatal infections flow cytometry lymphocytes Immunologic diseases. Allergy RC581-607 T. I. Dolgikh M. V. Shelyov E. V. Nesterenko T. N. Belkova IMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS
description	The study aimed to compare subset composition of peripheral blood lymphocytes in 40 newborns at different gestation periods, complicated by a verified prenatal infection (1st group), or with hypoxic brain damage (2nd group), using a flow cytometry technique. It was found that activated CD14+HLA-DR+ monocytes were 2,3-fold more common in the infants from the 1st group, and representation of CD5+CD19+ B1 lymphocytes (a «forbidden» clone) was 1,8-fold higher than in 2nd group. Among pre-term babies from the 1st group, the lymphocytes with CD3+CD16+/CD56+, CD3+CD95+ and CD5+CD19+ phenotype were registered more often, than in full-term infants (resp., 5, 11, and 2 times higher). These data argue for involvement of compensatory defense immune mechanisms under the conditions of increased antigenic load, being more pronounced in pre-term infants.
format	article
author	T. I. Dolgikh M. V. Shelyov E. V. Nesterenko T. N. Belkova
author_facet	T. I. Dolgikh M. V. Shelyov E. V. Nesterenko T. N. Belkova
author_sort	T. I. Dolgikh
title	IMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS
title_short	IMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS
title_full	IMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS
title_fullStr	IMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS
title_full_unstemmed	IMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS
title_sort	immunophenotyping of blood lymphocytes in newborns with prenatal infections at different gestation terms
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/bfcdc641c6e544e6958b8754f87d2907
work_keys_str_mv	AT tidolgikh immunophenotypingofbloodlymphocytesinnewbornswithprenatalinfectionsatdifferentgestationterms AT mvshelyov immunophenotypingofbloodlymphocytesinnewbornswithprenatalinfectionsatdifferentgestationterms AT evnesterenko immunophenotypingofbloodlymphocytesinnewbornswithprenatalinfectionsatdifferentgestationterms AT tnbelkova immunophenotypingofbloodlymphocytesinnewbornswithprenatalinfectionsatdifferentgestationterms
_version_	1718422565646499840

IMMUNOPHENOTYPING OF BLOOD LYMPHOCYTES IN NEWBORNS WITH PRENATAL INFECTIONS AT DIFFERENT GESTATION TERMS

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