Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease

Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease

Agathe Bridoux,1,2 Stephane Moutereau,3 Ala Covali-Noroc,1 Laurent Margarit,1 Stephane Palfi,4 Jean-Paul Nguyen,5 Jean-Pascal Lefaucheur,1,2 Pierre Césaro,6 Marie-Pia d'Ortho,7 Xavier Drouot1,21Service de Physiologie, Groupe Henri Mondor, 2Faculté de Médecine...

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Autores principales: Bridoux A, Moutereau S, Covali-Noroc A, Margarit L, Palfi S, Nguyen JP, Lefaucheur JP, Césaro P, d’Ortho MP, Drouot X
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
Materias:
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
Acceso en línea:https://doaj.org/article/bfce472e5cbb4a0da46c899f0d8d0c68
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spelling oai:doaj.org-article:bfce472e5cbb4a0da46c899f0d8d0c682021-12-02T03:41:43ZVentricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease1179-1608https://doaj.org/article/bfce472e5cbb4a0da46c899f0d8d0c682013-06-01T00:00:00Zhttp://www.dovepress.com/ventricular-orexin-a-hypocretin-1-levels-correlate-with-rapid-eye-move-a13321https://doaj.org/toc/1179-1608Agathe Bridoux,1,2 Stephane Moutereau,3 Ala Covali-Noroc,1 Laurent Margarit,1 Stephane Palfi,4 Jean-Paul Nguyen,5 Jean-Pascal Lefaucheur,1,2 Pierre Césaro,6 Marie-Pia d'Ortho,7 Xavier Drouot1,21Service de Physiologie, Groupe Henri Mondor, 2Faculté de Médecine, Université Paris Est Créteil, 3Service de Biochimie, Groupe Henri Mondor, 4UF Neurochirurgie Fonctionnelle, Groupe Henri Mondor, Créteil, France; 5Service de Neurochirurgie, Hôpital Nord Laënnec, Nantes, France; 6Service de Neurologie, Groupe Henri Mondor, Créteil, France; 7Service de Physiologie, Groupe Bichat – Claude Bernard, Paris, FranceObjective: Patients with Parkinson's disease frequently complain of sleep disturbances and loss of muscle atonia during rapid-eye-movement (REM) sleep is not rare. The orexin-A (hypocretin-1) hypothalamic system plays a central role in controlling REM sleep. Loss of orexin neurons results in narcolepsy-cataplexy, a condition characterized by diurnal sleepiness and REM sleep without atonia. Alterations in the orexin-A system have been also documented in Parkinson's disease, but whether these alterations have clinical consequences remains unknown.Methods: Here, we measured orexin-A levels in ventricular cerebrospinal fluid from eight patients with Parkinson's disease (four males and four females) who underwent ventriculography during deep brain-stimulation surgery and performed full-night polysomnography before surgery.Results: Our results showed a positive correlation between orexin-A levels and REM sleep without muscle atonia.Conclusion: Our results suggest that high levels of orexin-A in Parkinson's disease may be associated with loss of REM muscle atonia.Keywords: Parkinson, orexin-A, ventricular CSF, REM atoniaBridoux AMoutereau SCovali-Noroc AMargarit LPalfi SNguyen JPLefaucheur JPCésaro Pd’Ortho MPDrouot XDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2013, Iss default, Pp 87-91 (2013)
institution DOAJ
collection DOAJ
language EN
topic Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
spellingShingle Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
Bridoux A
Moutereau S
Covali-Noroc A
Margarit L
Palfi S
Nguyen JP
Lefaucheur JP
Césaro P
d’Ortho MP
Drouot X
Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
description Agathe Bridoux,1,2 Stephane Moutereau,3 Ala Covali-Noroc,1 Laurent Margarit,1 Stephane Palfi,4 Jean-Paul Nguyen,5 Jean-Pascal Lefaucheur,1,2 Pierre Césaro,6 Marie-Pia d'Ortho,7 Xavier Drouot1,21Service de Physiologie, Groupe Henri Mondor, 2Faculté de Médecine, Université Paris Est Créteil, 3Service de Biochimie, Groupe Henri Mondor, 4UF Neurochirurgie Fonctionnelle, Groupe Henri Mondor, Créteil, France; 5Service de Neurochirurgie, Hôpital Nord Laënnec, Nantes, France; 6Service de Neurologie, Groupe Henri Mondor, Créteil, France; 7Service de Physiologie, Groupe Bichat – Claude Bernard, Paris, FranceObjective: Patients with Parkinson's disease frequently complain of sleep disturbances and loss of muscle atonia during rapid-eye-movement (REM) sleep is not rare. The orexin-A (hypocretin-1) hypothalamic system plays a central role in controlling REM sleep. Loss of orexin neurons results in narcolepsy-cataplexy, a condition characterized by diurnal sleepiness and REM sleep without atonia. Alterations in the orexin-A system have been also documented in Parkinson's disease, but whether these alterations have clinical consequences remains unknown.Methods: Here, we measured orexin-A levels in ventricular cerebrospinal fluid from eight patients with Parkinson's disease (four males and four females) who underwent ventriculography during deep brain-stimulation surgery and performed full-night polysomnography before surgery.Results: Our results showed a positive correlation between orexin-A levels and REM sleep without muscle atonia.Conclusion: Our results suggest that high levels of orexin-A in Parkinson's disease may be associated with loss of REM muscle atonia.Keywords: Parkinson, orexin-A, ventricular CSF, REM atonia
format article
author Bridoux A
Moutereau S
Covali-Noroc A
Margarit L
Palfi S
Nguyen JP
Lefaucheur JP
Césaro P
d’Ortho MP
Drouot X
author_facet Bridoux A
Moutereau S
Covali-Noroc A
Margarit L
Palfi S
Nguyen JP
Lefaucheur JP
Césaro P
d’Ortho MP
Drouot X
author_sort Bridoux A
title Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
title_short Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
title_full Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
title_fullStr Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
title_full_unstemmed Ventricular orexin-A (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in Parkinson's disease
title_sort ventricular orexin-a (hypocretin-1) levels correlate with rapid-eye-movement sleep without atonia in parkinson's disease
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/bfce472e5cbb4a0da46c899f0d8d0c68
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