LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells

Abstract Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor and an oncogene product, which plays a pivotal role in tumor progression. Therefore, targeting persistent STAT3 signaling directly is an attractive anticancer strategy. The aim of this study is to test the...

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Détails bibliographiques
Auteurs principaux: Xiang Chen, Li Pan, Jia Wei, Ruijie Zhang, Xiaozhi Yang, Jinhua Song, Ren-Yuan Bai, Shengling Fu, Christopher R. Pierson, Jonathan L. Finlay, Chenglong Li, Jiayuh Lin
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/bfd18968512a4e99a84e2b1b85bb2f69
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