Nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device

Abstract To offer an enhanced and well-controlled nicotine delivery from the refill liquid to the aerosol is a key point to adequately satisfy nicotine cravings using electronic nicotine delivery systems (ENDS). A recent high-power ENDS, exhibiting higher aerosol nicotine delivery than older technol...

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Autores principales:	Nathalie Prévôt, Fabien de Oliveira, Sophie Perinel-Ragey, Thierry Basset, Jean-Michel Vergnon, Jérémie Pourchez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bfd1a041cdad4f1d962daeccca2f7a3b
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spelling	oai:doaj.org-article:bfd1a041cdad4f1d962daeccca2f7a3b2021-12-02T16:06:34ZNicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device10.1038/s41598-017-03008-02045-2322https://doaj.org/article/bfd1a041cdad4f1d962daeccca2f7a3b2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03008-0https://doaj.org/toc/2045-2322Abstract To offer an enhanced and well-controlled nicotine delivery from the refill liquid to the aerosol is a key point to adequately satisfy nicotine cravings using electronic nicotine delivery systems (ENDS). A recent high-power ENDS, exhibiting higher aerosol nicotine delivery than older technologies, was used. The particle size distribution was measured using a cascade impactor. The effects of the refill liquid composition on the nicotine content of each size-fraction in the submicron range were investigated. Nicotine was quantified by liquid chromatography coupled with tandem mass spectrometry. Particle size distribution of the airborne refill liquid and the aerosol nicotine demonstrated that the nicotine is equally distributed in droplets regardless of their size. Results also proved that the nicotine concentration in aerosol was significantly lower compared to un-puffed refill liquid. A part of the nicotine may be left in the ENDS upon depletion, and consequently a portion of the nicotine may not be transferred to the user. Thus, new generation high-power ENDS associated with propylene glycol/vegetable glycerin (PG/VG) based solvent were very efficient to generate carrier-droplets containing nicotine molecules with a constant concentration. Findings highlighted that a portion of the nicotine in the refill liquid may not be transferred to the user.Nathalie PrévôtFabien de OliveiraSophie Perinel-RageyThierry BassetJean-Michel VergnonJérémie PourchezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nathalie Prévôt Fabien de Oliveira Sophie Perinel-Ragey Thierry Basset Jean-Michel Vergnon Jérémie Pourchez Nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device
description	Abstract To offer an enhanced and well-controlled nicotine delivery from the refill liquid to the aerosol is a key point to adequately satisfy nicotine cravings using electronic nicotine delivery systems (ENDS). A recent high-power ENDS, exhibiting higher aerosol nicotine delivery than older technologies, was used. The particle size distribution was measured using a cascade impactor. The effects of the refill liquid composition on the nicotine content of each size-fraction in the submicron range were investigated. Nicotine was quantified by liquid chromatography coupled with tandem mass spectrometry. Particle size distribution of the airborne refill liquid and the aerosol nicotine demonstrated that the nicotine is equally distributed in droplets regardless of their size. Results also proved that the nicotine concentration in aerosol was significantly lower compared to un-puffed refill liquid. A part of the nicotine may be left in the ENDS upon depletion, and consequently a portion of the nicotine may not be transferred to the user. Thus, new generation high-power ENDS associated with propylene glycol/vegetable glycerin (PG/VG) based solvent were very efficient to generate carrier-droplets containing nicotine molecules with a constant concentration. Findings highlighted that a portion of the nicotine in the refill liquid may not be transferred to the user.
format	article
author	Nathalie Prévôt Fabien de Oliveira Sophie Perinel-Ragey Thierry Basset Jean-Michel Vergnon Jérémie Pourchez
author_facet	Nathalie Prévôt Fabien de Oliveira Sophie Perinel-Ragey Thierry Basset Jean-Michel Vergnon Jérémie Pourchez
author_sort	Nathalie Prévôt
title	Nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device
title_short	Nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device
title_full	Nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device
title_fullStr	Nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device
title_full_unstemmed	Nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device
title_sort	nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bfd1a041cdad4f1d962daeccca2f7a3b
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Nicotine delivery from the refill liquid to the aerosol via high-power e-cigarette device

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