EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS

Abstract. Some molecular biomarkers of peripheral blood mononuclear cells (PBMC) were studied in patients 18 to 30 years old with community-acquired pneumonia (n = 30) and healthy persons (n = 15), along with testing appropriate biological effects of low-intensity microwave irradiation (1000 MHz), a...

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Autores principales:	I. V. Terekhov, K. A. Solodukhin, V. S. Nikiforov, M. S. Gromov, V. K. Parfenyk, S. S. Bondar
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	microwave radiation mononuclear cells cytokines transcription factors pneumonia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bfd5454e41694c1cb527c124167ef270
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spelling	oai:doaj.org-article:bfd5454e41694c1cb527c124167ef2702021-11-18T08:03:42ZEFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS1563-06252313-741X10.15789/1563-0625-2012-6-541-544https://doaj.org/article/bfd5454e41694c1cb527c124167ef2702014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/614https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Some molecular biomarkers of peripheral blood mononuclear cells (PBMC) were studied in patients 18 to 30 years old with community-acquired pneumonia (n = 30) and healthy persons (n = 15), along with testing appropriate biological effects of low-intensity microwave irradiation (1000 MHz), at a dose rate of 100 pW/cm2. Concentrations of cytokines and some molecules providing intracellular signal transduction in PBMC were measured by ELISA tests. Biological action of microwave radiation was studied after 1-hour irradiation of whole blood, followed by incubation for 24 hours. A single round of irradiation was shown to cause an increase in NFκB content by 12.5% (р = 0.001); IκB by 21.1% (р = 0.0007); phosphorylated JNK1/2, by 18.2% (р = 0.052); p21 protein amounts, by 56.2% (р = 0.031); IL-2, by 8.5% (р = 0.08); IL-4, by 17.6% (р = 0.031). Antioxidant potential of PBMC supernatewas augmented by 65.2% (р < 0,001). Hence, a single 1000-MHz microwave irradiation modulates activity of intracellular events in PBMCs from pneumonia patients.I. V. TerekhovK. A. SolodukhinV. S. NikiforovM. S. GromovV. K. ParfenykS. S. BondarSPb RAACIarticlemicrowave radiationmononuclear cellscytokinestranscription factorspneumoniaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 6, Pp 541-544 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	microwave radiation mononuclear cells cytokines transcription factors pneumonia Immunologic diseases. Allergy RC581-607
spellingShingle	microwave radiation mononuclear cells cytokines transcription factors pneumonia Immunologic diseases. Allergy RC581-607 I. V. Terekhov K. A. Solodukhin V. S. Nikiforov M. S. Gromov V. K. Parfenyk S. S. Bondar EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS
description	Abstract. Some molecular biomarkers of peripheral blood mononuclear cells (PBMC) were studied in patients 18 to 30 years old with community-acquired pneumonia (n = 30) and healthy persons (n = 15), along with testing appropriate biological effects of low-intensity microwave irradiation (1000 MHz), at a dose rate of 100 pW/cm2. Concentrations of cytokines and some molecules providing intracellular signal transduction in PBMC were measured by ELISA tests. Biological action of microwave radiation was studied after 1-hour irradiation of whole blood, followed by incubation for 24 hours. A single round of irradiation was shown to cause an increase in NFκB content by 12.5% (р = 0.001); IκB by 21.1% (р = 0.0007); phosphorylated JNK1/2, by 18.2% (р = 0.052); p21 protein amounts, by 56.2% (р = 0.031); IL-2, by 8.5% (р = 0.08); IL-4, by 17.6% (р = 0.031). Antioxidant potential of PBMC supernatewas augmented by 65.2% (р < 0,001). Hence, a single 1000-MHz microwave irradiation modulates activity of intracellular events in PBMCs from pneumonia patients.
format	article
author	I. V. Terekhov K. A. Solodukhin V. S. Nikiforov M. S. Gromov V. K. Parfenyk S. S. Bondar
author_facet	I. V. Terekhov K. A. Solodukhin V. S. Nikiforov M. S. Gromov V. K. Parfenyk S. S. Bondar
author_sort	I. V. Terekhov
title	EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS
title_short	EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS
title_full	EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS
title_fullStr	EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS
title_full_unstemmed	EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS
title_sort	effects of low-intensity microwave irradiation upon intracellular signaling of mononuclear cells in pneumonia patients
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/bfd5454e41694c1cb527c124167ef270
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_version_	1718422504639299584

EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS

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