M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1...

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Autores principales:	Indira Bag, Shue Chen, Leah F. Rosin, Yang Chen, Chen-Yu Liu, Guo-Yun Yu, Elissa P. Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bfd88957d63142eab7e9c576f5008e93
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spelling	oai:doaj.org-article:bfd88957d63142eab7e9c576f5008e932021-12-02T15:40:02ZM1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity10.1038/s41467-021-24407-y2041-1723https://doaj.org/article/bfd88957d63142eab7e9c576f5008e932021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24407-yhttps://doaj.org/toc/2041-1723Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders.Indira BagShue ChenLeah F. RosinYang ChenChen-Yu LiuGuo-Yun YuElissa P. LeiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Indira Bag Shue Chen Leah F. Rosin Yang Chen Chen-Yu Liu Guo-Yun Yu Elissa P. Lei M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
description	Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders.
format	article
author	Indira Bag Shue Chen Leah F. Rosin Yang Chen Chen-Yu Liu Guo-Yun Yu Elissa P. Lei
author_facet	Indira Bag Shue Chen Leah F. Rosin Yang Chen Chen-Yu Liu Guo-Yun Yu Elissa P. Lei
author_sort	Indira Bag
title	M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
title_short	M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
title_full	M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
title_fullStr	M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
title_full_unstemmed	M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
title_sort	m1bp cooperates with cp190 to activate transcription at tad borders and promote chromatin insulator activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bfd88957d63142eab7e9c576f5008e93
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M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

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