Effect of oral antihyperglycemic drugs on purine metabolism

Gout and diabetes mellitus are metabolic diseases, the pathogenesis of which is based on an excess of organic molecules in the body, in the first case — uric acid (UA), in the second — glucose. It is assumed that UA can also be involved in the pathogenesis of type 2 diabetes mellitus (T2DM), while i...

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Autor principal:	T. S. Panevin
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	type 2 diabetes mellitus gout hyperuricemia uric acid Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/bfdc2e10a3f64db3b5c3bb819ea5eaec
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spelling	oai:doaj.org-article:bfdc2e10a3f64db3b5c3bb819ea5eaec2021-11-14T09:00:23ZEffect of oral antihyperglycemic drugs on purine metabolism2072-03512072-037810.14341/DM12756https://doaj.org/article/bfdc2e10a3f64db3b5c3bb819ea5eaec2021-11-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12756https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Gout and diabetes mellitus are metabolic diseases, the pathogenesis of which is based on an excess of organic molecules in the body, in the first case — uric acid (UA), in the second — glucose. It is assumed that UA can also be involved in the pathogenesis of type 2 diabetes mellitus (T2DM), while insulin resistance and hyperglycemia affect purine metabolism. Both diseases are associated with an increased risk of cardiovascular events. In addition, chronic microcrystalline inflammation, which is absent in asymptomatic hyperuricemia, but is an obligatory component of gout, is probably an independent factor in T2DM, arterial hypertension, and cardiovascular events. The treatment of both diseases is strategically similar: in gout, the goal is to achieve a normal blood MC level, in T2DM — to normalize glycemia, and the frequent combination of these metabolic diseases requires taking into account the effect of drug therapy on concomitant diseases. Most modern antihyperglycemic drugs can affect purine metabolism, which is confirmed by the results of a number of foreign works. At the same time, the effect of T2DM therapy on purine metabolism and gout has not been adequately covered in the domestic literature, which was the purpose of this review.T. S. PanevinEndocrinology Research Centrearticletype 2 diabetes mellitusgouthyperuricemiauric acidNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 24, Iss 4, Pp 342-349 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus gout hyperuricemia uric acid Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus gout hyperuricemia uric acid Nutritional diseases. Deficiency diseases RC620-627 T. S. Panevin Effect of oral antihyperglycemic drugs on purine metabolism
description	Gout and diabetes mellitus are metabolic diseases, the pathogenesis of which is based on an excess of organic molecules in the body, in the first case — uric acid (UA), in the second — glucose. It is assumed that UA can also be involved in the pathogenesis of type 2 diabetes mellitus (T2DM), while insulin resistance and hyperglycemia affect purine metabolism. Both diseases are associated with an increased risk of cardiovascular events. In addition, chronic microcrystalline inflammation, which is absent in asymptomatic hyperuricemia, but is an obligatory component of gout, is probably an independent factor in T2DM, arterial hypertension, and cardiovascular events. The treatment of both diseases is strategically similar: in gout, the goal is to achieve a normal blood MC level, in T2DM — to normalize glycemia, and the frequent combination of these metabolic diseases requires taking into account the effect of drug therapy on concomitant diseases. Most modern antihyperglycemic drugs can affect purine metabolism, which is confirmed by the results of a number of foreign works. At the same time, the effect of T2DM therapy on purine metabolism and gout has not been adequately covered in the domestic literature, which was the purpose of this review.
format	article
author	T. S. Panevin
author_facet	T. S. Panevin
author_sort	T. S. Panevin
title	Effect of oral antihyperglycemic drugs on purine metabolism
title_short	Effect of oral antihyperglycemic drugs on purine metabolism
title_full	Effect of oral antihyperglycemic drugs on purine metabolism
title_fullStr	Effect of oral antihyperglycemic drugs on purine metabolism
title_full_unstemmed	Effect of oral antihyperglycemic drugs on purine metabolism
title_sort	effect of oral antihyperglycemic drugs on purine metabolism
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/bfdc2e10a3f64db3b5c3bb819ea5eaec
work_keys_str_mv	AT tspanevin effectoforalantihyperglycemicdrugsonpurinemetabolism
_version_	1718429486651801600

Effect of oral antihyperglycemic drugs on purine metabolism

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