Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).

<h4>Background</h4>Preterm birth is a leading cause of perinatal mortality, yet the evolutionary history of this obstetrical syndrome is largely unknown in nonhuman primate species.<h4>Methodology/principal findings</h4>We examined the length of gestation during pregnancies t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Derek E Wildman, Monica Uddin, Roberto Romero, Juan M Gonzalez, Nandor Gabor Than, Jim Murphy, Zhuo-Cheng Hou, Jo Fritz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bfe47a2a49ff4639a6dc594e91656bdf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bfe47a2a49ff4639a6dc594e91656bdf
record_format	dspace
spelling	oai:doaj.org-article:bfe47a2a49ff4639a6dc594e91656bdf2021-11-04T06:08:24ZSpontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).1932-620310.1371/journal.pone.0024509https://doaj.org/article/bfe47a2a49ff4639a6dc594e91656bdf2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21949724/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Preterm birth is a leading cause of perinatal mortality, yet the evolutionary history of this obstetrical syndrome is largely unknown in nonhuman primate species.<h4>Methodology/principal findings</h4>We examined the length of gestation during pregnancies that occurred in a captive chimpanzee colony by inspecting veterinary and behavioral records spanning a total of thirty years. Upon examination of these records we were able to confidently estimate gestation length for 93 of the 97 (96%) pregnancies recorded at the colony. In total, 78 singleton gestations resulted in live birth, and from these pregnancies we estimated the mean gestation length of normal chimpanzee pregnancies to be 228 days, a finding consistent with other published reports. We also calculated that the range of gestation in normal chimpanzee pregnancies is approximately forty days. Of the remaining fifteen pregnancies, only one of the offspring survived, suggesting viability for chimpanzees requires a gestation of approximately 200 days. These fifteen pregnancies constitute spontaneous abortions and preterm deliveries, for which the upper gestational age limit was defined as 2 SD from the mean length of gestation (208 days).<h4>Conclusions/significance</h4>The present study documents that preterm birth occurred within our study population of captive chimpanzees. As in humans, pregnancy loss is not uncommon in chimpanzees, In addition, our findings indicate that both humans and chimpanzees show a similar range of normal variation in gestation length, suggesting this was the case at the time of their last common ancestor (LCA). Nevertheless, our data suggest that whereas chimpanzees' normal gestation length is ∼20-30 days after reaching viability, humans' normal gestation length is approximately 50 days beyond the estimated date of viability without medical intervention. Future research using a comparative evolutionary framework should help to clarify the extent to which mechanisms at work in normal and preterm parturition are shared in these species.Derek E WildmanMonica UddinRoberto RomeroJuan M GonzalezNandor Gabor ThanJim MurphyZhuo-Cheng HouJo FritzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24509 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Derek E Wildman Monica Uddin Roberto Romero Juan M Gonzalez Nandor Gabor Than Jim Murphy Zhuo-Cheng Hou Jo Fritz Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).
description	<h4>Background</h4>Preterm birth is a leading cause of perinatal mortality, yet the evolutionary history of this obstetrical syndrome is largely unknown in nonhuman primate species.<h4>Methodology/principal findings</h4>We examined the length of gestation during pregnancies that occurred in a captive chimpanzee colony by inspecting veterinary and behavioral records spanning a total of thirty years. Upon examination of these records we were able to confidently estimate gestation length for 93 of the 97 (96%) pregnancies recorded at the colony. In total, 78 singleton gestations resulted in live birth, and from these pregnancies we estimated the mean gestation length of normal chimpanzee pregnancies to be 228 days, a finding consistent with other published reports. We also calculated that the range of gestation in normal chimpanzee pregnancies is approximately forty days. Of the remaining fifteen pregnancies, only one of the offspring survived, suggesting viability for chimpanzees requires a gestation of approximately 200 days. These fifteen pregnancies constitute spontaneous abortions and preterm deliveries, for which the upper gestational age limit was defined as 2 SD from the mean length of gestation (208 days).<h4>Conclusions/significance</h4>The present study documents that preterm birth occurred within our study population of captive chimpanzees. As in humans, pregnancy loss is not uncommon in chimpanzees, In addition, our findings indicate that both humans and chimpanzees show a similar range of normal variation in gestation length, suggesting this was the case at the time of their last common ancestor (LCA). Nevertheless, our data suggest that whereas chimpanzees' normal gestation length is ∼20-30 days after reaching viability, humans' normal gestation length is approximately 50 days beyond the estimated date of viability without medical intervention. Future research using a comparative evolutionary framework should help to clarify the extent to which mechanisms at work in normal and preterm parturition are shared in these species.
format	article
author	Derek E Wildman Monica Uddin Roberto Romero Juan M Gonzalez Nandor Gabor Than Jim Murphy Zhuo-Cheng Hou Jo Fritz
author_facet	Derek E Wildman Monica Uddin Roberto Romero Juan M Gonzalez Nandor Gabor Than Jim Murphy Zhuo-Cheng Hou Jo Fritz
author_sort	Derek E Wildman
title	Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).
title_short	Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).
title_full	Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).
title_fullStr	Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).
title_full_unstemmed	Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).
title_sort	spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (pan troglodytes).
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/bfe47a2a49ff4639a6dc594e91656bdf
work_keys_str_mv	AT derekewildman spontaneousabortionandpretermlaboranddeliveryinnonhumanprimatesevidencefromacaptivecolonyofchimpanzeespantroglodytes AT monicauddin spontaneousabortionandpretermlaboranddeliveryinnonhumanprimatesevidencefromacaptivecolonyofchimpanzeespantroglodytes AT robertoromero spontaneousabortionandpretermlaboranddeliveryinnonhumanprimatesevidencefromacaptivecolonyofchimpanzeespantroglodytes AT juanmgonzalez spontaneousabortionandpretermlaboranddeliveryinnonhumanprimatesevidencefromacaptivecolonyofchimpanzeespantroglodytes AT nandorgaborthan spontaneousabortionandpretermlaboranddeliveryinnonhumanprimatesevidencefromacaptivecolonyofchimpanzeespantroglodytes AT jimmurphy spontaneousabortionandpretermlaboranddeliveryinnonhumanprimatesevidencefromacaptivecolonyofchimpanzeespantroglodytes AT zhuochenghou spontaneousabortionandpretermlaboranddeliveryinnonhumanprimatesevidencefromacaptivecolonyofchimpanzeespantroglodytes AT jofritz spontaneousabortionandpretermlaboranddeliveryinnonhumanprimatesevidencefromacaptivecolonyofchimpanzeespantroglodytes
_version_	1718445174537846784

Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes).

Ejemplares similares