Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death

Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properti...

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Autores principales:	K. Hayashi, F. Nikolos, Y. C. Lee, A. Jain, E. Tsouko, H. Gao, A. Kasabyan, H. E. Leung, A. Osipov, S. Y. Jung, A. V. Kurtova, K. S. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bfe5d024758a491d9f637bb1c6537137
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spelling	oai:doaj.org-article:bfe5d024758a491d9f637bb1c65371372021-12-02T13:23:48ZTipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death10.1038/s41467-020-19970-92041-1723https://doaj.org/article/bfe5d024758a491d9f637bb1c65371372020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19970-9https://doaj.org/toc/2041-1723Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered by the concomitant release of the inhibitory DAMP PGE2.K. HayashiF. NikolosY. C. LeeA. JainE. TsoukoH. GaoA. KasabyanH. E. LeungA. OsipovS. Y. JungA. V. KurtovaK. S. ChanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q K. Hayashi F. Nikolos Y. C. Lee A. Jain E. Tsouko H. Gao A. Kasabyan H. E. Leung A. Osipov S. Y. Jung A. V. Kurtova K. S. Chan Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
description	Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered by the concomitant release of the inhibitory DAMP PGE2.
format	article
author	K. Hayashi F. Nikolos Y. C. Lee A. Jain E. Tsouko H. Gao A. Kasabyan H. E. Leung A. Osipov S. Y. Jung A. V. Kurtova K. S. Chan
author_facet	K. Hayashi F. Nikolos Y. C. Lee A. Jain E. Tsouko H. Gao A. Kasabyan H. E. Leung A. Osipov S. Y. Jung A. V. Kurtova K. S. Chan
author_sort	K. Hayashi
title	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_short	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_full	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_fullStr	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_full_unstemmed	Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
title_sort	tipping the immunostimulatory and inhibitory damp balance to harness immunogenic cell death
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bfe5d024758a491d9f637bb1c6537137
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Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death

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