Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study

Introduction: Oral fluoroquinolones and tetracyclines are known to interact with divalent or trivalent cation-containing compounds (DTCCs) via chelation. The objective of this study is to describe the prevalence of these drug-drug interactions (DDIs) in an inpatient setting. Methods: A cross-section...

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Autores principales:	Khalid Eljaaly, Asalah Helal, Tamather Almandeel, Rawan Algarni, Samah Alshehri
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Fluoroquinolone Quinolone Tetracycline Mineral Complexation Interaction Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bfed1b55f47044d6a3c00e1fac557b22
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spelling	oai:doaj.org-article:bfed1b55f47044d6a3c00e1fac557b222021-11-20T04:56:30ZMultivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study1319-562X10.1016/j.sjbs.2021.07.065https://doaj.org/article/bfed1b55f47044d6a3c00e1fac557b222021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X2100646Xhttps://doaj.org/toc/1319-562XIntroduction: Oral fluoroquinolones and tetracyclines are known to interact with divalent or trivalent cation-containing compounds (DTCCs) via chelation. The objective of this study is to describe the prevalence of these drug-drug interactions (DDIs) in an inpatient setting. Methods: A cross-sectional study of prospectively collected data were conducted at an academic tertiary care hospital. We included hospitalized adults who were receiving oral fluoroquinolones or tetracyclines with DTCCs in 2019. Our hospital uses electronic health records for medication ordering and handwritten medication administration records (MARs). The primary study outcome was the percentage of simultaneous administration of fluoroquinolones or tetracyclines with DTCCs, and the secondary outcome was the percentage of inappropriate separation time. Results: Among patients who received oral fluoroquinolones or tetracyclines, 47 patients (26.6%) were co-administered DTCCs and included in this study. Ciprofloxacin (n = 29; 61.7%) was the most commonly interacting antibiotic, followed by moxifloxacin (n = 12; 25.5%) and doxycycline (n = 6; 12.8%). The interacting DTCCs included iron-containing products and calcium-containing products, and half of the patients (n = 24; 51%) received DTCCs once daily. Most patients (n = 35; 74.5%) were found to receive oral fluoroquinolones or tetracyclines at the same time as DTCCs, while one (2.1%) received inappropriately separated DTCCs. Conclusions: Despite being a very known contraindicated DDI, the prevalence of simultaneous co-administration of oral fluoroquinolones or tetracyclines with polyvalent cations was extremely high in a hospital with handwritten MARs. Antimicrobial stewardship programs should target this DDI, and future studies should evaluate the impact of different practical solutions to this problem in different clinical settings.Khalid EljaalyAsalah HelalTamather AlmandeelRawan AlgarniSamah AlshehriElsevierarticleFluoroquinoloneQuinoloneTetracyclineMineralComplexationInteractionBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 6929-6932 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fluoroquinolone Quinolone Tetracycline Mineral Complexation Interaction Biology (General) QH301-705.5
spellingShingle	Fluoroquinolone Quinolone Tetracycline Mineral Complexation Interaction Biology (General) QH301-705.5 Khalid Eljaaly Asalah Helal Tamather Almandeel Rawan Algarni Samah Alshehri Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study
description	Introduction: Oral fluoroquinolones and tetracyclines are known to interact with divalent or trivalent cation-containing compounds (DTCCs) via chelation. The objective of this study is to describe the prevalence of these drug-drug interactions (DDIs) in an inpatient setting. Methods: A cross-sectional study of prospectively collected data were conducted at an academic tertiary care hospital. We included hospitalized adults who were receiving oral fluoroquinolones or tetracyclines with DTCCs in 2019. Our hospital uses electronic health records for medication ordering and handwritten medication administration records (MARs). The primary study outcome was the percentage of simultaneous administration of fluoroquinolones or tetracyclines with DTCCs, and the secondary outcome was the percentage of inappropriate separation time. Results: Among patients who received oral fluoroquinolones or tetracyclines, 47 patients (26.6%) were co-administered DTCCs and included in this study. Ciprofloxacin (n = 29; 61.7%) was the most commonly interacting antibiotic, followed by moxifloxacin (n = 12; 25.5%) and doxycycline (n = 6; 12.8%). The interacting DTCCs included iron-containing products and calcium-containing products, and half of the patients (n = 24; 51%) received DTCCs once daily. Most patients (n = 35; 74.5%) were found to receive oral fluoroquinolones or tetracyclines at the same time as DTCCs, while one (2.1%) received inappropriately separated DTCCs. Conclusions: Despite being a very known contraindicated DDI, the prevalence of simultaneous co-administration of oral fluoroquinolones or tetracyclines with polyvalent cations was extremely high in a hospital with handwritten MARs. Antimicrobial stewardship programs should target this DDI, and future studies should evaluate the impact of different practical solutions to this problem in different clinical settings.
format	article
author	Khalid Eljaaly Asalah Helal Tamather Almandeel Rawan Algarni Samah Alshehri
author_facet	Khalid Eljaaly Asalah Helal Tamather Almandeel Rawan Algarni Samah Alshehri
author_sort	Khalid Eljaaly
title	Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study
title_short	Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study
title_full	Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study
title_fullStr	Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study
title_full_unstemmed	Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study
title_sort	multivalent cations interactions with fluoroquinolones or tetracyclines: a cross-sectional study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/bfed1b55f47044d6a3c00e1fac557b22
work_keys_str_mv	AT khalideljaaly multivalentcationsinteractionswithfluoroquinolonesortetracyclinesacrosssectionalstudy AT asalahhelal multivalentcationsinteractionswithfluoroquinolonesortetracyclinesacrosssectionalstudy AT tamatheralmandeel multivalentcationsinteractionswithfluoroquinolonesortetracyclinesacrosssectionalstudy AT rawanalgarni multivalentcationsinteractionswithfluoroquinolonesortetracyclinesacrosssectionalstudy AT samahalshehri multivalentcationsinteractionswithfluoroquinolonesortetracyclinesacrosssectionalstudy
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Multivalent cations interactions with fluoroquinolones or tetracyclines: A cross-sectional study

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