Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo

How transcription factors regulate cell fates in native tissues is unclear. Here, the authors report that differential chromatin binding of NKX2-1 determines opposing alveolar cell fates in the murine lung, showing loss of YAP/TAZ directs NKX2-1 to alternative binding sites leading to cell fate conv...

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Autores principales:	Danielle R. Little, Anne M. Lynch, Yun Yan, Haruhiko Akiyama, Shioko Kimura, Jichao Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bfeffd85c5f54b10be715552e0177ba1
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spelling	oai:doaj.org-article:bfeffd85c5f54b10be715552e0177ba12021-12-02T15:38:20ZDifferential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo10.1038/s41467-021-22817-62041-1723https://doaj.org/article/bfeffd85c5f54b10be715552e0177ba12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22817-6https://doaj.org/toc/2041-1723How transcription factors regulate cell fates in native tissues is unclear. Here, the authors report that differential chromatin binding of NKX2-1 determines opposing alveolar cell fates in the murine lung, showing loss of YAP/TAZ directs NKX2-1 to alternative binding sites leading to cell fate conversion.Danielle R. LittleAnne M. LynchYun YanHaruhiko AkiyamaShioko KimuraJichao ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Danielle R. Little Anne M. Lynch Yun Yan Haruhiko Akiyama Shioko Kimura Jichao Chen Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo
description	How transcription factors regulate cell fates in native tissues is unclear. Here, the authors report that differential chromatin binding of NKX2-1 determines opposing alveolar cell fates in the murine lung, showing loss of YAP/TAZ directs NKX2-1 to alternative binding sites leading to cell fate conversion.
format	article
author	Danielle R. Little Anne M. Lynch Yun Yan Haruhiko Akiyama Shioko Kimura Jichao Chen
author_facet	Danielle R. Little Anne M. Lynch Yun Yan Haruhiko Akiyama Shioko Kimura Jichao Chen
author_sort	Danielle R. Little
title	Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo
title_short	Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo
title_full	Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo
title_fullStr	Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo
title_full_unstemmed	Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo
title_sort	differential chromatin binding of the lung lineage transcription factor nkx2-1 resolves opposing murine alveolar cell fates in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bfeffd85c5f54b10be715552e0177ba1
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Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo

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