Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations
Associations of copy number variations (CNVs) with complex traits are challenging to study because of their low frequency. Here, the authors analyse SNP array and array comparative genomic hybridization data of 100,028 individuals and report their associations with immune-related, cardiometabolic an...
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Nature Portfolio
2020
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oai:doaj.org-article:bff05ccd6ca145f18966c6e073fcf8bb2021-12-02T13:27:30ZRare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations10.1038/s41467-019-13624-12041-1723https://doaj.org/article/bff05ccd6ca145f18966c6e073fcf8bb2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13624-1https://doaj.org/toc/2041-1723Associations of copy number variations (CNVs) with complex traits are challenging to study because of their low frequency. Here, the authors analyse SNP array and array comparative genomic hybridization data of 100,028 individuals and report their associations with immune-related, cardiometabolic and neuropsychiatric diseases as well as cancer.Yun Rose LiJoseph T. GlessnerBradley P. CoeJin LiMaede MohebnasabXiao ChangJohn ConnollyCharlly KaoZhi WeiJonathan BradfieldCecilia KimCuiping HouMunir KhanFrank MentchHaijun QiuMarina BakayChristopher CardinaleMaria LemmaDebra AbramsAndrew Bridglall-JhingoorMeckenzie BehrShanell HarrisonGeorge OtienoAlexandria ThomasFengxiang WangRosetta ChiavacciLawrence WuDexter HadleyElizabeth GoldmuntzJosephine EliaJohn MarisRobert GrundmeierMarcella DevotoBrendan KeatingMichael MarchRenata PellagrinoStruan F. A. GrantPatrick M. A. SleimanMingyao LiEvan E. EichlerHakon HakonarsonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yun Rose Li Joseph T. Glessner Bradley P. Coe Jin Li Maede Mohebnasab Xiao Chang John Connolly Charlly Kao Zhi Wei Jonathan Bradfield Cecilia Kim Cuiping Hou Munir Khan Frank Mentch Haijun Qiu Marina Bakay Christopher Cardinale Maria Lemma Debra Abrams Andrew Bridglall-Jhingoor Meckenzie Behr Shanell Harrison George Otieno Alexandria Thomas Fengxiang Wang Rosetta Chiavacci Lawrence Wu Dexter Hadley Elizabeth Goldmuntz Josephine Elia John Maris Robert Grundmeier Marcella Devoto Brendan Keating Michael March Renata Pellagrino Struan F. A. Grant Patrick M. A. Sleiman Mingyao Li Evan E. Eichler Hakon Hakonarson Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations |
| description |
Associations of copy number variations (CNVs) with complex traits are challenging to study because of their low frequency. Here, the authors analyse SNP array and array comparative genomic hybridization data of 100,028 individuals and report their associations with immune-related, cardiometabolic and neuropsychiatric diseases as well as cancer. |
| format |
article |
| author |
Yun Rose Li Joseph T. Glessner Bradley P. Coe Jin Li Maede Mohebnasab Xiao Chang John Connolly Charlly Kao Zhi Wei Jonathan Bradfield Cecilia Kim Cuiping Hou Munir Khan Frank Mentch Haijun Qiu Marina Bakay Christopher Cardinale Maria Lemma Debra Abrams Andrew Bridglall-Jhingoor Meckenzie Behr Shanell Harrison George Otieno Alexandria Thomas Fengxiang Wang Rosetta Chiavacci Lawrence Wu Dexter Hadley Elizabeth Goldmuntz Josephine Elia John Maris Robert Grundmeier Marcella Devoto Brendan Keating Michael March Renata Pellagrino Struan F. A. Grant Patrick M. A. Sleiman Mingyao Li Evan E. Eichler Hakon Hakonarson |
| author_facet |
Yun Rose Li Joseph T. Glessner Bradley P. Coe Jin Li Maede Mohebnasab Xiao Chang John Connolly Charlly Kao Zhi Wei Jonathan Bradfield Cecilia Kim Cuiping Hou Munir Khan Frank Mentch Haijun Qiu Marina Bakay Christopher Cardinale Maria Lemma Debra Abrams Andrew Bridglall-Jhingoor Meckenzie Behr Shanell Harrison George Otieno Alexandria Thomas Fengxiang Wang Rosetta Chiavacci Lawrence Wu Dexter Hadley Elizabeth Goldmuntz Josephine Elia John Maris Robert Grundmeier Marcella Devoto Brendan Keating Michael March Renata Pellagrino Struan F. A. Grant Patrick M. A. Sleiman Mingyao Li Evan E. Eichler Hakon Hakonarson |
| author_sort |
Yun Rose Li |
| title |
Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations |
| title_short |
Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations |
| title_full |
Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations |
| title_fullStr |
Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations |
| title_full_unstemmed |
Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations |
| title_sort |
rare copy number variants in over 100,000 european ancestry subjects reveal multiple disease associations |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/bff05ccd6ca145f18966c6e073fcf8bb |
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