Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility
The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune...
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2020
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oai:doaj.org-article:bff7e82d5b6d44f0880ccdf00acf35df2021-12-02T16:49:30ZImmune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility10.1038/s41467-019-13855-22041-1723https://doaj.org/article/bff7e82d5b6d44f0880ccdf00acf35df2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13855-2https://doaj.org/toc/2041-1723The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune-related pathwaysLinda KachuriMattias JohanssonSara R. RashkinRebecca E. GraffYohan BosséVenkata ManemNeil E. CaporasoMaria Teresa LandiDavid C. ChristianiPaolo VineisGeoffrey LiuGhislaine SceloDavid ZaridzeSanjay S. SheteDemetrius AlbanesMelinda C. AldrichAdonina TardónGad RennertChu ChenGary E. GoodmanJennifer A. DohertyHeike BickeböllerJohn K. FieldMichael P. DaviesM. Dawn TeareLambertus A. KiemeneyStig E. BojesenAage HaugenShanbeh ZienolddinyStephen LamLoïc Le MarchandIona ChengMatthew B. SchabathEric J. DuellAngeline S. AndrewJonas ManjerPhilip LazarusSusanne ArnoldJames D. McKayNima C. EmamiMatthew T. WarkentinYonathan BrhaneMa’en ObeidatRichard M. MartinCaroline ReltonGeorge Davey SmithPhilip C. HaycockChristopher I. AmosPaul BrennanJohn S. WitteRayjean J. HungNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Linda Kachuri Mattias Johansson Sara R. Rashkin Rebecca E. Graff Yohan Bossé Venkata Manem Neil E. Caporaso Maria Teresa Landi David C. Christiani Paolo Vineis Geoffrey Liu Ghislaine Scelo David Zaridze Sanjay S. Shete Demetrius Albanes Melinda C. Aldrich Adonina Tardón Gad Rennert Chu Chen Gary E. Goodman Jennifer A. Doherty Heike Bickeböller John K. Field Michael P. Davies M. Dawn Teare Lambertus A. Kiemeney Stig E. Bojesen Aage Haugen Shanbeh Zienolddiny Stephen Lam Loïc Le Marchand Iona Cheng Matthew B. Schabath Eric J. Duell Angeline S. Andrew Jonas Manjer Philip Lazarus Susanne Arnold James D. McKay Nima C. Emami Matthew T. Warkentin Yonathan Brhane Ma’en Obeidat Richard M. Martin Caroline Relton George Davey Smith Philip C. Haycock Christopher I. Amos Paul Brennan John S. Witte Rayjean J. Hung Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| description |
The role of impaired lung function in lung cancer etiology is complex due to the relation of cigarette smoking to both conditions. Here, supported by Mendelian randomization analysis the authors find a link between pulmonary function impairment and lung cancer risk beyond smoking, implicating immune-related pathways |
| format |
article |
| author |
Linda Kachuri Mattias Johansson Sara R. Rashkin Rebecca E. Graff Yohan Bossé Venkata Manem Neil E. Caporaso Maria Teresa Landi David C. Christiani Paolo Vineis Geoffrey Liu Ghislaine Scelo David Zaridze Sanjay S. Shete Demetrius Albanes Melinda C. Aldrich Adonina Tardón Gad Rennert Chu Chen Gary E. Goodman Jennifer A. Doherty Heike Bickeböller John K. Field Michael P. Davies M. Dawn Teare Lambertus A. Kiemeney Stig E. Bojesen Aage Haugen Shanbeh Zienolddiny Stephen Lam Loïc Le Marchand Iona Cheng Matthew B. Schabath Eric J. Duell Angeline S. Andrew Jonas Manjer Philip Lazarus Susanne Arnold James D. McKay Nima C. Emami Matthew T. Warkentin Yonathan Brhane Ma’en Obeidat Richard M. Martin Caroline Relton George Davey Smith Philip C. Haycock Christopher I. Amos Paul Brennan John S. Witte Rayjean J. Hung |
| author_facet |
Linda Kachuri Mattias Johansson Sara R. Rashkin Rebecca E. Graff Yohan Bossé Venkata Manem Neil E. Caporaso Maria Teresa Landi David C. Christiani Paolo Vineis Geoffrey Liu Ghislaine Scelo David Zaridze Sanjay S. Shete Demetrius Albanes Melinda C. Aldrich Adonina Tardón Gad Rennert Chu Chen Gary E. Goodman Jennifer A. Doherty Heike Bickeböller John K. Field Michael P. Davies M. Dawn Teare Lambertus A. Kiemeney Stig E. Bojesen Aage Haugen Shanbeh Zienolddiny Stephen Lam Loïc Le Marchand Iona Cheng Matthew B. Schabath Eric J. Duell Angeline S. Andrew Jonas Manjer Philip Lazarus Susanne Arnold James D. McKay Nima C. Emami Matthew T. Warkentin Yonathan Brhane Ma’en Obeidat Richard M. Martin Caroline Relton George Davey Smith Philip C. Haycock Christopher I. Amos Paul Brennan John S. Witte Rayjean J. Hung |
| author_sort |
Linda Kachuri |
| title |
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_short |
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_full |
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_fullStr |
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_full_unstemmed |
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| title_sort |
immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/bff7e82d5b6d44f0880ccdf00acf35df |
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