Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding site followed by activation of RhoA-ROCK-MKK4/7-JNK s...

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Autores principales: Florian Haun, Simon Neumann, Lukas Peintner, Katrin Wieland, Jüri Habicht, Carsten Schwan, Kristine Østevold, Maria Magdalena Koczorowska, Martin Biniossek, Matthias Kist, Hauke Busch, Melanie Boerries, Roger J. Davis, Ulrich Maurer, Oliver Schilling, Klaus Aktories, Christoph Borner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/bff8d4a17fd0485f978c20944875f2fe
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Sumario:Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding site followed by activation of RhoA-ROCK-MKK4/7-JNK signalling leading to Bim-mediated anoikis.

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